@article{Lee:2013:10.1016/j.cell.2013.08.034,
author = {Lee, JC and Espéli, M and Anderson, CA and Linterman, MA and Pocock, JM and Williams, NJ and Roberts, R and Viatte, S and Fu, B and Peshu, N and Hien, TT and Phu, NH and Wesley, E and Edwards, C and Ahmad, T and Mansfield, JC and Gearry, R and Dunstan, S and Williams, TN and Barton, A and Vinuesa, CG and Parkes, M and Lyons, PA and Smith, KGC},
doi = {10.1016/j.cell.2013.08.034},
journal = {Cell},
pages = {57--69},
title = {Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway},
url = {http://dx.doi.org/10.1016/j.cell.2013.08.034},
volume = {155},
year = {2013}
}

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TY  - JOUR
AB  - The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on a patient’s life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into the role of genetics in prognosis. We identify a noncoding polymorphism in FOXO3A (rs12212067: T > G) at which the minor (G) allele, despite not being associated with disease susceptibility, is associated with a milder course of Crohn’s disease and rheumatoid arthritis and with increased risk of severe malaria. Minor allele carriage is shown to limit inflammatory responses in monocytes via a FOXO3-driven pathway, which through TGFβ1 reduces production of proinflammatory cytokines, including TNFα, and increases production of anti-inflammatory cytokines, including IL-10. Thus, we uncover a shared genetic contribution to prognosis in distinct diseases that operates via a FOXO3-driven pathway modulating inflammatory responses.
AU  - Lee,JC
AU  - Espéli,M
AU  - Anderson,CA
AU  - Linterman,MA
AU  - Pocock,JM
AU  - Williams,NJ
AU  - Roberts,R
AU  - Viatte,S
AU  - Fu,B
AU  - Peshu,N
AU  - Hien,TT
AU  - Phu,NH
AU  - Wesley,E
AU  - Edwards,C
AU  - Ahmad,T
AU  - Mansfield,JC
AU  - Gearry,R
AU  - Dunstan,S
AU  - Williams,TN
AU  - Barton,A
AU  - Vinuesa,CG
AU  - Parkes,M
AU  - Lyons,PA
AU  - Smith,KGC
DO  - 10.1016/j.cell.2013.08.034
EP  - 69
PY  - 2013///
SN  - 0092-8674
SP  - 57
TI  - Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2013.08.034
UR  - http://www.scopus.com/inward/record.url?eid=2-s2.0-84884851276&partnerID=40&md5=fc7378b2bbad239cca44e95634dd0f01
UR  - https://www.sciencedirect.com/science/article/pii/S0092867413010283?via%3Dihub
UR  - http://hdl.handle.net/10044/1/81648
VL  - 155
ER  - 

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