@article{Piel:2014:10.1016/S2214-109X(13)70150-5,
author = {Piel, FB and Tatem, AJ and Huang, Z and Gupta, S and Williams, TN and Weatherall, DJ},
doi = {10.1016/S2214-109X(13)70150-5},
journal = {The Lancet Global Health},
pages = {e80--e89},
title = {Global migration and the changing distribution of sickle haemoglobin: A quantitative study of temporal trends between 1960 and 2000},
url = {http://dx.doi.org/10.1016/S2214-109X(13)70150-5},
volume = {2},
year = {2014}
}

Download

TY  - JOUR
AB  - BackgroundChanges in the geographical distribution of genetic disorders are often thought to happen slowly, especially when compared with infectious diseases. Whereas mutations, genetic drift, and natural selection take place over many generations, epidemics can spread through large populations within a few days or weeks. Nevertheless, population movements can interfere with these processes, and few studies have been done of their effect on genetic disorders. We aimed to investigate the effect of global migration on the distribution of the sickle-cell gene—the most common and clinically significant haemoglobin structural variant.MethodsFor each country, we extracted data from the World Bank's Global Bilateral Migration Database about international human migrations between 1960 and 2000. We combined this information with evidence-based estimates of national HbS allele frequencies, generated within a Bayesian geostatistical framework, to analyse temporal changes in the net numbers of migrants, and classified countries with an index summarising these temporal trends.FindingsThe number of international migrants increased from 92·6 million in 1960, to 165·2 million in 2000. The estimated global number of migrants with HbS increased from about 1·6 million in 1960, to 3·6 million in 2000. This increase was largely due to an increase in the number of migrants from countries with HbS allele frequencies higher than 10%, from 3·1 million in 1960, to 14·2 million in 2000. Additionally, the mean number of countries of origin for each destination country increased from 70 (SE 46) in 1960, to 98 (48) in 2000, showing an increasing diversity in the network of international migrations between countries. Our index of change map shows a patchy distribution of the magnitude of temporal changes, with the highest positive and negative values scattered across all continents.InterpretationGlobal human population movements have had a substanti
AU  - Piel,FB
AU  - Tatem,AJ
AU  - Huang,Z
AU  - Gupta,S
AU  - Williams,TN
AU  - Weatherall,DJ
DO  - 10.1016/S2214-109X(13)70150-5
EP  - 89
PY  - 2014///
SN  - 2214-109X
SP  - 80
TI  - Global migration and the changing distribution of sickle haemoglobin: A quantitative study of temporal trends between 1960 and 2000
T2  - The Lancet Global Health
UR  - http://dx.doi.org/10.1016/S2214-109X(13)70150-5
UR  - http://www.scopus.com/inward/record.url?eid=2-s2.0-84892951517&partnerID=40&md5=abba9bfaceac18e452611637c6d58df1
UR  - https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(13)70150-5/fulltext#articleInformation
VL  - 2
ER  - 

Download