@article{Rockett:2014:10.1038/ng.3107,
author = {Rockett, KA and Clarke, GM and Fitzpatrick, K and Hubbart, C and Jeffreys, AE and Rowlands, K and Craik, R and Jallow, M and Conway, DJ and Bojang, KA and Pinder, M and Usen, S and Sisay-Joof, F and Sirugo, G and Toure, O and Thera, MA and Konate, S and Sissoko, S and Niangaly, A and Poudiougou, B and Mangano, VD and Bougouma, EC and Sirima, SB and Modiano, D and Amenga-Etego, LN and Ghansah, A and Koram, KA and Wilson, MD and Enimil, A and Evans, J and Amodu, O and Olaniyan, S and Apinjoh, T and Mugri, R and Ndi, A and Ndila, CM and Uyoga, S and Macharia, A and Peshu, N and Williams, TN and Manjurano, A and Riley, E and Drakeley, C and Reyburn, H and Nyirongo, V and Kachala, D and Molyneux, M and Dunstan, SJ and Phu, NH and Quyen, NTN and Thai, CQ and Hien, TT and Manning, L and Laman, M and Siba, P and Karunajeewa, H and Allen, S and Allen, A and Davis, TME and Michon, P and Mueller, I and Green, A and Molloy, S and Johnson, KJ and Kerasidou, A and Cornelius, V and Hart, L and Vander},
doi = {10.1038/ng.3107},
journal = {Nature Genetics},
pages = {1197--1204},
title = {Reappraisal of known malaria resistance loci in a large multicenter study},
url = {http://dx.doi.org/10.1038/ng.3107},
volume = {46},
year = {2014}
}

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TY  - JOUR
AB  - Many human genetic associations with resistance to malaria have been reported, but few have been reliably replicated. We collected data on 11,890 cases of severe malaria due to Plasmodium falciparum and 17,441 controls from 12 locations in Africa, Asia and Oceania. We tested 55 SNPs in 27 loci previously reported to associate with severe malaria. There was evidence of association at P < 1 × 10−4 with the HBB, ABO, ATP2B4, G6PD and CD40LG loci, but previously reported associations at 22 other loci did not replicate in the multicenter analysis. The large sample size made it possible to identify authentic genetic effects that are heterogeneous across populations or phenotypes, with a striking example being the main African form of G6PD deficiency, which reduced the risk of cerebral malaria but increased the risk of severe malarial anemia. The finding that G6PD deficiency has opposing effects on different fatal complications of P. falciparum infection indicates that the evolutionary origins of this common human genetic disorder are more complex than previously supposed.
AU  - Rockett,KA
AU  - Clarke,GM
AU  - Fitzpatrick,K
AU  - Hubbart,C
AU  - Jeffreys,AE
AU  - Rowlands,K
AU  - Craik,R
AU  - Jallow,M
AU  - Conway,DJ
AU  - Bojang,KA
AU  - Pinder,M
AU  - Usen,S
AU  - Sisay-Joof,F
AU  - Sirugo,G
AU  - Toure,O
AU  - Thera,MA
AU  - Konate,S
AU  - Sissoko,S
AU  - Niangaly,A
AU  - Poudiougou,B
AU  - Mangano,VD
AU  - Bougouma,EC
AU  - Sirima,SB
AU  - Modiano,D
AU  - Amenga-Etego,LN
AU  - Ghansah,A
AU  - Koram,KA
AU  - Wilson,MD
AU  - Enimil,A
AU  - Evans,J
AU  - Amodu,O
AU  - Olaniyan,S
AU  - Apinjoh,T
AU  - Mugri,R
AU  - Ndi,A
AU  - Ndila,CM
AU  - Uyoga,S
AU  - Macharia,A
AU  - Peshu,N
AU  - Williams,TN
AU  - Manjurano,A
AU  - Riley,E
AU  - Drakeley,C
AU  - Reyburn,H
AU  - Nyirongo,V
AU  - Kachala,D
AU  - Molyneux,M
AU  - Dunstan,SJ
AU  - Phu,NH
AU  - Quyen,NTN
AU  - Thai,CQ
AU  - Hien,TT
AU  - Manning,L
AU  - Laman,M
AU  - Siba,P
AU  - Karunajeewa,H
AU  - Allen,S
AU  - Allen,A
AU  - Davis,TME
AU  - Michon,P
AU  - Mueller,I
AU  - Green,A
AU  - Molloy,S
AU  - Johnson,KJ
AU  - Kerasidou,A
AU  - Cornelius,V
AU  - Hart,L
AU  - Vanderwal,A
AU  - Joaquin,M
AU  - Band,G
AU  - Le,SQ
AU  - Pirinen,M
AU  - Sepúlveda,N
AU  - Spencer,CCA
AU  - Clark,TG
AU  - Agbenyega,T
AU  - Achidi,E
AU  - Doumbo,O
AU  - Farrar,J
AU  - Marsh,K
AU  - Taylor,T
AU  - Kwiatkowski,DP
DO  - 10.1038/ng.3107
EP  - 1204
PY  - 2014///
SN  - 1061-4036
SP  - 1197
TI  - Reappraisal of known malaria resistance loci in a large multicenter study
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/ng.3107
UR  - http://www.scopus.com/inward/record.url?eid=2-s2.0-84908885451&partnerID=40&md5=8da492c20aef9d5bfbc5a9cdc7c3fc12
VL  - 46
ER  - 

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