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• Journal article
  Bejon P, Williams TN, Nyundo C, Hay SI, Benz D, Gething PW, Otiende M, Peshu J, Bashraheil M, Greenhouse B, Bousema T, Bauni E, Marsh K, Smith DL, Borrmann Set al., 2014,

  A micro-epidemiological analysis of febrile malaria in coastal Kenya showing hotspots within hotspots

  , eLife, Vol: 2014
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• Journal article
  Etyang AO, Munge K, Bunyasi EW, Matata L, Ndila C, Kapesa S, Owiti M, Khandwalla I, Brent AJ, Tsofa B, Kabibu P, Morpeth S, Bauni E, Otiende M, Ojal J, Ayieko P, Knoll MD, Smeeth L, Williams TN, Griffiths UK, Scott JAGet al., 2014,

  Burden of disease in adults admitted to hospital in a rural region of coastal Kenya: An analysis of data from linked clinical and demographic surveillance systems

  , The Lancet Global Health, Vol: 2, Pages: E216-E224
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• Journal article
  Atkinson SH, Armitage AE, Khandwala S, Mwangi TW, Uyoga S, Bejon PA, Williams TN, Prentice AM, Drakesmith Het al., 2014,

  Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children

  , Blood, Vol: 123, Pages: 3221-3229
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• Journal article
  Church K, 2014,

  Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: A systematic review

  , BMC Medicine, Vol: 12
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• Journal article
  Hodgson SH, Juma E, Salim A, Magiri C, Kimani D, Njenga D, Muia A, Cole AO, Ogwang C, Awuondo K, Lowe B, Munene M, Billingsley PF, James ER, Gunasekera A, Sim BKL, Njuguna P, Rampling TW, Richman A, Abebe Y, Kamuyu G, Muthui M, Elias SC, Molyneux S, Gerry S, Macharia A, Williams TN, Bull PC, Hill AVS, Osier FH, Draper SJ, Bejon P, Hoffman SL, Ogutu B, Marsh Ket al., 2014,

  Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection

  , Frontiers in Microbiology, Vol: 5
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• Journal article
  Lee JC, Espéli M, Anderson CA, Linterman MA, Pocock JM, Williams NJ, Roberts R, Viatte S, Fu B, Peshu N, Hien TT, Phu NH, Wesley E, Edwards C, Ahmad T, Mansfield JC, Gearry R, Dunstan S, Williams TN, Barton A, Vinuesa CG, Parkes M, Lyons PA, Smith KGCet al., 2013,

  Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway

  , Cell, Vol: 155, Pages: 57-69, ISSN: 0092-8674

  The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on a patient’s life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into the role of genetics in prognosis. We identify a noncoding polymorphism in FOXO3A (rs12212067: T > G) at which the minor (G) allele, despite not being associated with disease susceptibility, is associated with a milder course of Crohn’s disease and rheumatoid arthritis and with increased risk of severe malaria. Minor allele carriage is shown to limit inflammatory responses in monocytes via a FOXO3-driven pathway, which through TGFβ1 reduces production of proinflammatory cytokines, including TNFα, and increases production of anti-inflammatory cytokines, including IL-10. Thus, we uncover a shared genetic contribution to prognosis in distinct diseases that operates via a FOXO3-driven pathway modulating inflammatory responses.

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• Journal article
  Kariuki SM, Rockett K, Clark TG, Reyburn H, Agbenyega T, Taylor TE, Birbeck GL, Williams TN, Newton CRJCet al., 2013,

  The genetic risk of acute seizures in African children with falciparum malaria

  , Epilepsia, Vol: 54, Pages: 990-1001
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• Journal article
  Piel FB, Hay SI, Gupta S, Weatherall DJ, Williams TNet al., 2013,

  Global Burden of Sickle Cell Anaemia in Children under Five, 2010-2050: Modelling Based on Demographics, Excess Mortality, and Interventions

  , PLoS Medicine, Vol: 10
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• Journal article
  Marsh V, Kombe F, Fitzpatrick R, Williams TN, Parker M, Molyneux Set al., 2013,

  Consulting communities on feedback of genetic findings in international health research: Sharing sickle cell disease and carrier information in coastal Kenya

  , BMC Medical Ethics, Vol: 14
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• Journal article
  Bond T, Templeton MR, 2011,

  History and future of domestic biogas plants in the developing world

  , Energy for Sustainable Development, Vol: 15, Pages: 347-354, ISSN: 0973-0826
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