@article{Messager:2016:10.1002/anie.201604677,
author = {Messager, L and Burns, JR and Kim, J and Cecchin, D and Hindley, J and Pyne, ALB and Gaitzsch, J and Battaglia, G and Howorka, S},
doi = {10.1002/anie.201604677},
journal = {Angewandte Chemie International Edition},
pages = {11106--11109},
title = {Biomimetic hybrid nanocontainers with selective permeability},
url = {http://dx.doi.org/10.1002/anie.201604677},
volume = {55},
year = {2016}
}

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TY  - JOUR
AB  - Chemistry plays a crucial role in creating synthetic analogues of biomacromolecular structures. Of particular scientific and technological interest are biomimetic vesicles that are inspired by natural membrane compartments and organelles but avoid their drawbacks, such as membrane instability and limited control over cargo transport across the boundaries. In this study, completely synthetic vesicles were developed from stable polymeric walls and easytoengineer membrane DNA nanopores. The hybrid nanocontainers feature selective permeability and permit the transport of organic molecules of 1.5nm size. Larger enzymes (ca. 5nm) can be encapsulated and retained within the vesicles yet remain catalytically active. The hybrid structures constitute a new type of enzymatic nanoreactor. The high tunability of the polymeric vesicles and DNA pores will be key in tailoring the nanocontainers for applications in drug delivery, bioimaging, biocatalysis, and cell mimicry.
AU  - Messager,L
AU  - Burns,JR
AU  - Kim,J
AU  - Cecchin,D
AU  - Hindley,J
AU  - Pyne,ALB
AU  - Gaitzsch,J
AU  - Battaglia,G
AU  - Howorka,S
DO  - 10.1002/anie.201604677
EP  - 11109
PY  - 2016///
SN  - 1521-3757
SP  - 11106
TI  - Biomimetic hybrid nanocontainers with selective permeability
T2  - Angewandte Chemie International Edition
UR  - http://dx.doi.org/10.1002/anie.201604677
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383642300024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/68773
VL  - 55
ER  - 

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