The application of metabonomics in a clinical and surgical setting was first introduced by Professor Jeremy Nicholson et al. (Nature 491, 384–392). The CPC conducts research with the aim of achieving patient stratification through metabolic phenotyping. The resulting metabolic profiles contain diagnostic and mechanistic information which can be translated to improved patient care. The studies analysed at the Centre cover a spectrum of diseases including cancer, parasitic infections, viral infections, allergy and neurological conditions.

In parallel to patient phenotyping, the CPC, within the academic Divison of Division of Systems Medicine, is continuously developing the clinical application of metabonomics through the use of global metabolic profiling of novel sample matrices or the introduction of novel validated targeted methods. 

A list of selected publications showing how metabonomics is applied in stratified medicine is presented below.

Published research

Any questions?

For all enquiries please contact:

cpc@imperial.ac.uk