In this section
@article{Kuc:2021:10.1007/s00213-021-05999-1,
author = {Kuc, J and Kettner, H and Rosas, F and Erritzoe, D and Haijen, E and Kaelen, M and Nutt, D and Carhart-Harris, RL},
doi = {10.1007/s00213-021-05999-1},
journal = {Psychopharmacology},
pages = {1425--1440},
title = {Psychedelic experience dose-dependently modulated by cannabis: results of a prospective online survey},
url = {http://dx.doi.org/10.1007/s00213-021-05999-1},
volume = {239},
year = {2021}
}
TY - JOUR
AB - Rationale.Classic psychedelics are currently being studied as novel treatments for a range of psychiatric disorders. However, research on how psychedelics interact with other psychoactive substances remains scarce.ObjectivesThe current study aimed to explore the subjective effects of psychedelics when used alongside cannabis.MethodsParticipants (n = 321) completed a set of online surveys at 2 time points: 7 days before, and 1 day after a planned experience with a serotonergic psychedelic. The collected data included demographics, environmental factors (so-called setting) and five validated questionnaires: Mystical Experience Questionnaire (MEQ), visual subscales of Altered States of Consciousness Questionnaire (ASC-Vis), Challenging Experience Questionnaire (CEQ), Ego Dissolution Inventory (EDI) and Emotional Breakthrough Inventory (EBI). Participants were grouped according to whether they had reported using no cannabis (n = 195) or low (n = 53), medium (n = 45) or high (n = 28) dose, directly concomitant with the psychedelic. Multivariate analysis of covariance (MANCOVA) and contrasts was used to analyse differences in subjective effects between groups while controlling for potential confounding contextual ‘setting’ variables.ResultsThe simultaneous use of cannabis together with classic serotonergic psychedelics was associated with more intense psychedelic experience across a range of measures: a linear relationship was found between dose and MEQ, ASC-Vis and EDI scores, while a quadratic relationship was found for CEQ scores. No relationship was found between the dose of cannabis and the EBI.ConclusionsResults imply a possible interaction between the cannabis and psychedelic on acute subjective experiences; however, design limitations hamper our ability to draw firm inferences on directions of causality and the clinical implications of any such interactions.
AU - Kuc,J
AU - Kettner,H
AU - Rosas,F
AU - Erritzoe,D
AU - Haijen,E
AU - Kaelen,M
AU - Nutt,D
AU - Carhart-Harris,RL
DO - 10.1007/s00213-021-05999-1
EP - 1440
PY - 2021///
SN - 0033-3158
SP - 1425
TI - Psychedelic experience dose-dependently modulated by cannabis: results of a prospective online survey
T2 - Psychopharmacology
UR - http://dx.doi.org/10.1007/s00213-021-05999-1
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000714328200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://link.springer.com/article/10.1007/s00213-021-05999-1
UR - http://hdl.handle.net/10044/1/96549
VL - 239
ER -