@article{Ruffini:2023:10.1371/journal.pcbi.1010811,
author = {Ruffini, G and Damiani, G and Lozano-Soldevilla, D and Deco, N and Rosas, FE and Kiani, NA and Ponce-Alvarez, A and Kringelbach, ML and Carhart-Harris, R and Deco, G},
doi = {10.1371/journal.pcbi.1010811},
journal = {PLoS Computational Biology},
pages = {1--29},
title = {LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics},
url = {http://dx.doi.org/10.1371/journal.pcbi.1010811},
volume = {19},
year = {2023}
}

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TY  - JOUR
AB  - A topic of growing interest in computational neuroscience is the discovery of fundamental principles underlying global dynamics and the self-organization of the brain. In particular, the notion that the brain operates near criticality has gained considerable support, and recent work has shown that the dynamics of different brain states may be modeled by pairwise maximum entropy Ising models at various distances from a phase transition, i.e., from criticality. Here we aim to characterize two brain states (psychedelics-induced and placebo) as captured by functional magnetic resonance imaging (fMRI), with features derived from the Ising spin model formalism (system temperature, critical point, susceptibility) and from algorithmic complexity. We hypothesized, along the lines of the entropic brain hypothesis, that psychedelics drive brain dynamics into a more disordered state at a higher Ising temperature and increased complexity. We analyze resting state blood-oxygen-level-dependent (BOLD) fMRI data collected in an earlier study from fifteen subjects in a control condition (placebo) and during ingestion of lysergic acid diethylamide (LSD). Working with the automated anatomical labeling (AAL) brain parcellation, we first create "archetype" Ising models representative of the entire dataset (global) and of the data in each condition. Remarkably, we find that such archetypes exhibit a strong correlation with an average structural connectome template obtained from dMRI (r = 0.6). We compare the archetypes from the two conditions and find that the Ising connectivity in the LSD condition is lower than in the placebo one, especially in homotopic links (interhemispheric connectivity), reflecting a significant decrease of homotopic functional connectivity in the LSD condition. The global archetype is then personalized for each individual and condition by adjusting the system temperature. The resulting temperatures are all near but above the critical point of the model i
AU  - Ruffini,G
AU  - Damiani,G
AU  - Lozano-Soldevilla,D
AU  - Deco,N
AU  - Rosas,FE
AU  - Kiani,NA
AU  - Ponce-Alvarez,A
AU  - Kringelbach,ML
AU  - Carhart-Harris,R
AU  - Deco,G
DO  - 10.1371/journal.pcbi.1010811
EP  - 29
PY  - 2023///
SN  - 1553-734X
SP  - 1
TI  - LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics
T2  - PLoS Computational Biology
UR  - http://dx.doi.org/10.1371/journal.pcbi.1010811
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36735751
UR  - https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010811
UR  - http://hdl.handle.net/10044/1/102445
VL  - 19
ER  - 

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