In this section
@article{Montaldo:2018:10.1542/neo.19-12-e735,
author = {Montaldo, P and Lally, PJ and Oliveira, V and Thayyil, S},
doi = {10.1542/neo.19-12-e735},
journal = {NeoReviews.org},
pages = {e735--e741},
title = {Hypothermic neuroprotection for neonatal encephalopathy in low-and middle-income countries: a new approach to an old problem},
url = {http://dx.doi.org/10.1542/neo.19-12-e735},
volume = {19},
year = {2018}
}
TY - JOUR
AB - Little progress has been made over the past decade in improving the outcomes of infants with neonatal encephalopathy in low-and middle-income countries (LMICs), and millions of infants still die or sustain permanent neurodisability every year. One of the key reasons for this lack of progress is a disconnect between encephalopathy research in high-income countries and LMICs. The majority of the neonatal encephalopathy research has been conducted in high-income countries with a low disease burden, without the involvement of LMICs. Here we discuss how a collaborative approach—particularly between middle-income countries and high-income countries—enables the use of state-of-the-art magnetic resonance biomarkers and host gene expression profiling for effective disease stratification. Using the example of the Hypothermia for Encephalopathy in Low-and middle-Income countries (HELIX) trial, we describe how this approach may result in a paradigm shift in global perinatal brain research over the next decade.
AU - Montaldo,P
AU - Lally,PJ
AU - Oliveira,V
AU - Thayyil,S
DO - 10.1542/neo.19-12-e735
EP - 741
PY - 2018///
SN - 1526-9906
SP - 735
TI - Hypothermic neuroprotection for neonatal encephalopathy in low-and middle-income countries: a new approach to an old problem
T2 - NeoReviews.org
UR - http://dx.doi.org/10.1542/neo.19-12-e735
VL - 19
ER -
