@article{Shamshiri:2016:10.1002/hbm.23356,
author = {Shamshiri, EA and Tierney, TM and Centeno, M and St, Pier K and Pressler, RM and Sharp, DJ and Perani, S and Cross, JH and Carmichael, DW},
doi = {10.1002/hbm.23356},
journal = {Human Brain Mapping},
title = {Interictal activity is an important contributor to abnormal intrinsic network connectivity in paediatric focal epilepsy},
url = {http://dx.doi.org/10.1002/hbm.23356},
year = {2016}
}

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TY  - JOUR
AB  - Patients with focal epilepsy have been shown to have reduced functional connectivity in intrinsic connectivity networks (ICNs), which has been related to neurocognitive development and outcome. However, the relationship between interictal epileptiform discharges (IEDs) and changes in ICNs remains unclear, with evidence both for and against their influence. EEG-fMRI data was obtained in 27 children with focal epilepsy (mixed localisation and aetiologies) and 17 controls. A natural stimulus task (cartoon blocks verses blocks where the subject was told "please wait") was used to enhance the connectivity within networks corresponding to ICNs while reducing potential confounds of vigilance and motion. Our primary hypothesis was that the functional connectivity within visual and attention networks would be reduced in patients with epilepsy. We further hypothesized that controlling for the effects of IEDs would increase the connectivity in the patient group. The key findings were: (1) Patients with mixed epileptic foci showed a common connectivity reduction in lateral visual and attentional networks compared with controls. (2) Having controlled for the effects of IEDs there were no connectivity differences between patients and controls. (3) A comparison within patients revealed reduced connectivity between the attentional network and basal ganglia associated with interictal epileptiform discharges. We also found that the task activations were reduced in epilepsy patients but that this was unrelated to IED occurrence. Unexpectedly, connectivity changes in ICNs were strongly associated with the transient effects of interictal epileptiform discharges. Interictal epileptiform discharges were shown to have a pervasive transient influence on the brain's functional organisation. Hum Brain Mapp, 2016. © 2016 Wiley Periodicals, Inc.
AU  - Shamshiri,EA
AU  - Tierney,TM
AU  - Centeno,M
AU  - St,Pier K
AU  - Pressler,RM
AU  - Sharp,DJ
AU  - Perani,S
AU  - Cross,JH
AU  - Carmichael,DW
DO  - 10.1002/hbm.23356
PY  - 2016///
SN  - 1097-0193
TI  - Interictal activity is an important contributor to abnormal intrinsic network connectivity in paediatric focal epilepsy
T2  - Human Brain Mapping
UR  - http://dx.doi.org/10.1002/hbm.23356
ER  - 

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