In this section
@article{Whittington:2018:10.2967/jnumed.117.194720,
author = {Whittington, A and Sharp, DJ and Gunn, RN},
doi = {10.2967/jnumed.117.194720},
journal = {Journal of Nuclear Medicine},
pages = {822--827},
title = {Spatiotemporal distribution of β-amyloid in Alzheimer's disease results from heterogeneous regional carrying capacities},
url = {http://dx.doi.org/10.2967/jnumed.117.194720},
volume = {59},
year = {2018}
}
TY - JOUR
AB - β-amyloid (Aβ) accumulation in the brain is one of two pathological hallmarks of Alzheimer's Disease (AD) and its spatial distribution has been studied extensively ex vivo. We apply mathematical modelling to Aβ in vivo PET imaging data in order to investigate competing theories of Aβ spread in AD. Our results provide evidence that Aβ accumulation starts in all brain regions simultaneously and that its spatiotemporal distribution is a result of heterogeneous regional carrying capacities (regional maximum possible concentration of Aβ) for the aggregated protein rather than longer term spreading from seed regions.
AU - Whittington,A
AU - Sharp,DJ
AU - Gunn,RN
DO - 10.2967/jnumed.117.194720
EP - 827
PY - 2018///
SN - 1535-5667
SP - 822
TI - Spatiotemporal distribution of β-amyloid in Alzheimer's disease results from heterogeneous regional carrying capacities
T2 - Journal of Nuclear Medicine
UR - http://dx.doi.org/10.2967/jnumed.117.194720
UR - https://www.ncbi.nlm.nih.gov/pubmed/29146694
UR - http://hdl.handle.net/10044/1/54197
VL - 59
ER -
