@article{Vervoort:2018:10.7554/eLife.27706,
author = {Vervoort, SJ and de, Jong OG and Roukens, MG and Frederiks, CL and Vermeulen, JF and Lourenço, AR and Bella, L and Vidakovic, AT and Sandoval, JL and Moelans, C and van, Amersfoort M and Dallman, MJ and Bruna, A and Caldas, C and Nieuwenhuis, E and van, der Wall E and Derksen, P and van, Diest P and Verhaar, MC and Lam, EW-F and Mokry, M and Coffer, PJ},
doi = {10.7554/eLife.27706},
journal = {eLife},
title = {Global transcriptional analysis identifies a novel role for SOX4 in 2 tumor-induced angiogenesis},
url = {http://dx.doi.org/10.7554/eLife.27706},
volume = {7},
year = {2018}
}

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TY  - JOUR
AB  - The expression of the transcription factor SOX4 is increased in many human cancers, however, the pro-oncogenic capacity of SOX4 can vary greatly depending on the type of tumor. Both the contextual nature and the mechanisms underlying the pro-oncogenic SOX4 response remain unexplored. Here, we demonstrate that in mammary tumorigenesis, the SOX4 transcriptional network is dictated by the epigenome and is enriched for pro-angiogenic processes. We show that SOX4 directly regulates endothelin-1 (ET-1) expression and can thereby promote tumor-induced angiogenesis both in vitro and in vivo. Furthermore, in breast tumors, SOX4 expression correlates with blood vessel density and size, and predicts poor-prognosis in patients with breast cancer. Our data provide novel mechanistic insights into context-dependent SOX4 target gene selection, and uncover a novel pro-oncogenic role for this transcription factor in promoting tumor-induced angiogenesis. These findings establish a key role for SOX4 in promoting metastasis through exploiting diverse pro-tumorigenic pathways.
AU  - Vervoort,SJ
AU  - de,Jong OG
AU  - Roukens,MG
AU  - Frederiks,CL
AU  - Vermeulen,JF
AU  - Lourenço,AR
AU  - Bella,L
AU  - Vidakovic,AT
AU  - Sandoval,JL
AU  - Moelans,C
AU  - van,Amersfoort M
AU  - Dallman,MJ
AU  - Bruna,A
AU  - Caldas,C
AU  - Nieuwenhuis,E
AU  - van,der Wall E
AU  - Derksen,P
AU  - van,Diest P
AU  - Verhaar,MC
AU  - Lam,EW-F
AU  - Mokry,M
AU  - Coffer,PJ
DO  - 10.7554/eLife.27706
PY  - 2018///
SN  - 2050-084X
TI  - Global transcriptional analysis identifies a novel role for SOX4 in 2 tumor-induced angiogenesis
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.27706
UR  - http://hdl.handle.net/10044/1/66286
VL  - 7
ER  - 

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