BibTex format
@article{Hirschberg:1999:intimm/11.12.1927,
author = {Hirschberg, S and Layton, GT and Harris, SJ and Savage, N and Dallman, MJ and Lamb, JR},
doi = {intimm/11.12.1927},
journal = {Int Immunol},
pages = {1927--1934},
title = {CD4(+) T cells induced by virus-like particles expressing a major T cell epitope down-regulate IL-5 production in an ongoing immune response to Der p 1 independently of IFN-gamma production.},
url = {http://dx.doi.org/10.1093/intimm/11.12.1927},
volume = {11},
year = {1999}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - It has been previously demonstrated that hybrid Ty virus-like particles (VLP) prime effective CD8(+) and CD4(+) T cell responses. In this study, we investigated the effect of treating mice with Ty VLP carrying the immunodominant epitope of Der p 1 after sensitizing them to the group 1 allergen of the house dust mite Dermatophagoides pteronyssinus (Der p 1), under conditions that induce T(h)2 immunity. We show that i.p. treatment with the hybrid VLP abrogated allergen-specific IL-5 production and reduced allergen-specific cell proliferation. This suppression of the response was mediated by CD4(+) T cells and was not accompanied by an increase in IFN-gamma production.
AU - Hirschberg,S
AU - Layton,GT
AU - Harris,SJ
AU - Savage,N
AU - Dallman,MJ
AU - Lamb,JR
DO - intimm/11.12.1927
EP - 1934
PY - 1999///
SN - 0953-8178
SP - 1927
TI - CD4(+) T cells induced by virus-like particles expressing a major T cell epitope down-regulate IL-5 production in an ongoing immune response to Der p 1 independently of IFN-gamma production.
T2 - Int Immunol
UR - http://dx.doi.org/10.1093/intimm/11.12.1927
UR - https://www.ncbi.nlm.nih.gov/pubmed/10590258
VL - 11
ER -