Anaesthesia makes up the largest hospital speciality and has a huge role to play in nearly every aspect of any hospital from operating theatres to accident and emergency, to the labour ward, and to intensive care. Our research ranges from basic molecular research into mechanisms of anaesthesia to investigating the clinical impact of novel anaesthetic agents.
Our research covers the entirety of patient’s perioperative journey and through this, we aim to deliver the greatest impact. The section has been pioneering in the development of novel technologies to facilitate the delivery of anaesthetic agents and has also made pivotal in-roads into the mechanism of action of anaesthetic agents and their wider application to other diseases (such as their protective roles in brain injury and in cancer).
@article{Thakuria:2015:10.1016/j.jcrc.2015.09.021,
author = {Thakuria, L and Davey, R and Romano, R and Carby, MR and Kaul, S and Griffiths, MJ and Simon, AR and Reed, AK and Marczin, N},
doi = {10.1016/j.jcrc.2015.09.021},
journal = {Journal of Critical Care},
pages = {110--118},
title = {Mechanical ventilation after lung transplantation},
url = {http://dx.doi.org/10.1016/j.jcrc.2015.09.021},
volume = {31},
year = {2015}
}
TY - JOUR
AB - Introduction: To explore the hypothesis that early ventilation strategies influence clinical outcomes in lung transplantation,we have examined our routine ventilation practices in terms of tidal volumes (Vt) and inflation pressures.Methods: A total of 124 bilateral lung transplants between 2010 and 2013 were retrospectively assigned to low(b6 mL/kg), medium (6-8 mL/kg), and high (N8 mL/kg) Vt groups based on ventilation characteristics duringthe first 6 hours after surgery. Those same 124 patients were also stratified to low-pressure (b25 cm H2O) andhigh-pressure (≥25 cm H2O) groups.Results: Eighty percent of patients were ventilated using pressure control mode. Low, medium, and high Vt wereapplied to 10%, 43%, and 47% of patients, respectively. After correcting for patients requiring extracorporeal support,there was no difference in short-term to midterm outcomes among the different Vt groups. Low inflationpressures were applied to 61% of patients, who had a shorter length of intensive care unit stay (5 vs 12 days;P = .012), higher forced expiratory volume in 1 second at 3 months (77.8% vs 60.3%; P b .001), and increased6-month survival rate (95% vs 77%; P = .008).Conclusion: Low Vt ventilation has not been fully adopted in our practice. Ventilation with higher inflation pressures,but not Vt, was significantly associated with poorer outcomes after lung transplantation.
AU - Thakuria,L
AU - Davey,R
AU - Romano,R
AU - Carby,MR
AU - Kaul,S
AU - Griffiths,MJ
AU - Simon,AR
AU - Reed,AK
AU - Marczin,N
DO - 10.1016/j.jcrc.2015.09.021
EP - 118
PY - 2015///
SN - 0883-9441
SP - 110
TI - Mechanical ventilation after lung transplantation
T2 - Journal of Critical Care
UR - http://dx.doi.org/10.1016/j.jcrc.2015.09.021
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000366650500020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/48532
VL - 31
ER -