Patient with anaesthesiaAnaesthesia makes up the largest hospital speciality and has a huge role to play in nearly every aspect of any hospital from operating theatres to accident and emergency, to the labour ward, and to intensive care. Our research ranges from basic molecular research into mechanisms of anaesthesia to investigating the clinical impact of novel anaesthetic agents. 

Our research covers the entirety of patient’s perioperative journey and through this, we aim to deliver the greatest impact. The section has been pioneering in the development of novel technologies to facilitate the delivery of anaesthetic agents and has also made pivotal in-roads into the mechanism of action of anaesthetic agents and their wider application to other diseases (such as their protective roles in brain injury and in cancer).

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Citation

BibTex format

@article{Broad:2015:10.1016/j.nbd.2015.12.001,
author = {Broad, KD and Fierens, I and Fleiss, B and Rocha-Ferreira, E and Ezzati, M and Hassell, J and Alonso-Alconada, D and Bainbridge, A and Kawano, G and Ma, D and Tachtsidis, I and Gressens, P and Golay, X and Sanders, RD and Robertson, NJ},
doi = {10.1016/j.nbd.2015.12.001},
journal = {Neurobiology of Disease},
pages = {29--38},
title = {Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia},
url = {http://dx.doi.org/10.1016/j.nbd.2015.12.001},
volume = {87},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cooling to 33.5 °C in babies with neonatal encephalopathy significantly reduces death and disability, however additional therapies are needed to maximize brain protection. Following hypoxia–ischemia we assessed whether inhaled 45–50% Argon from 2–26 h augmented hypothermia neuroprotection in a neonatal piglet model, using MRS and aEEG, which predict outcome in babies with neonatal encephalopathy, and immunohistochemistry. Following cerebral hypoxia–ischemia, 20 Newborn male Large White piglets < 40 h were randomized to: (i) Cooling (33 °C) from 2–26 h (n = 10); or (ii) Cooling and inhaled 45–50% Argon (Cooling + Argon) from 2–26 h (n = 8). Whole-brain phosphorus-31 and regional proton MRS were acquired at baseline, 24 and 48 h after hypoxia–ischemia. EEG was monitored. At 48 h after hypoxia–ischemia, cell death (TUNEL) was evaluated over 7 brain regions. There were no differences in body weight, duration of hypoxia–ischemia or insult severity; throughout the study there were no differences in heart rate, arterial blood pressure, blood biochemistry and inotrope support. Two piglets in the Cooling + Argon group were excluded. Comparing Cooling + Argon with Cooling there was preservation of whole-brain MRS ATP and PCr/Pi at 48 h after hypoxia–ischemia (p < 0.001 for both) and lower 1H MRS lactate/N acetyl aspartate in white (p = 0.03 and 0.04) but not gray matter at 24 and 48 h. EEG background recovery was faster (p < 0.01) with Cooling + Argon. An overall difference between average cell-death of Cooling versus Cooling + Argon was observed (p < 0.01); estimated cells per mm2 were 23.9 points lower (95% C.I. 7.3–40.5) for the Cooling + Argon versus Cooling. Inhaled 45–50% Argon from 2–26 h augmented hypothermic protection at 48 h after hypoxia–ischemia shown by improved brain energy metabolism on MRS, faster EEG recovery and reduced cell death on TUNEL. Argon ma
AU  - Broad,KD
AU  - Fierens,I
AU  - Fleiss,B
AU  - Rocha-Ferreira,E
AU  - Ezzati,M
AU  - Hassell,J
AU  - Alonso-Alconada,D
AU  - Bainbridge,A
AU  - Kawano,G
AU  - Ma,D
AU  - Tachtsidis,I
AU  - Gressens,P
AU  - Golay,X
AU  - Sanders,RD
AU  - Robertson,NJ
DO  - 10.1016/j.nbd.2015.12.001
EP  - 38
PY  - 2015///
SN  - 1095-953X
SP  - 29
TI  - Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia
T2  - Neurobiology of Disease
UR  - http://dx.doi.org/10.1016/j.nbd.2015.12.001
UR  - http://hdl.handle.net/10044/1/40706
VL  - 87
ER  -
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