Patient with anaesthesiaAnaesthesia makes up the largest hospital speciality and has a huge role to play in nearly every aspect of any hospital from operating theatres to accident and emergency, to the labour ward, and to intensive care. Our research ranges from basic molecular research into mechanisms of anaesthesia to investigating the clinical impact of novel anaesthetic agents. 

Our research covers the entirety of patient’s perioperative journey and through this, we aim to deliver the greatest impact. The section has been pioneering in the development of novel technologies to facilitate the delivery of anaesthetic agents and has also made pivotal in-roads into the mechanism of action of anaesthetic agents and their wider application to other diseases (such as their protective roles in brain injury and in cancer).

Research themes:

Citation

BibTex format

@article{Vizcaychipi:2017:10.2174/1874321801711010075,
author = {Vizcaychipi, MP and Hua and Loganathan and williams and Balogun-Lynch and Dob},
doi = {10.2174/1874321801711010075},
journal = {Open Anesthesiology Journal},
pages = {75--82},
title = {Assessment of haemodynamic response to induction of general anaesthesia in healthy adult patients undergoing elective orthopaedic surgery by using a continuous non-invasive cardiovascular monitoring},
url = {http://dx.doi.org/10.2174/1874321801711010075},
volume = {11},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundContinuous cardiovascular monitoring as part of management of high-risk surgical patients is widely practiced, however continuous monitoring as part of routine management in low-risk surgical patients is unclear. Detailed monitoring of cardiovascular parameters from the pre-induction stage allows clinicians to individualise anaesthetic management in the perioperative period. Our aim was to investigate haemodynamic and Bispectral Index (BIS) changes in healthy patients undergoing surgery following induction of anaesthesia with propofol using a continuous non-invasive blood pressure device (LiDCOrapid™).MethodsThis prospective, observational single-centre study was conducted at a London teaching hospital between June-November 2014. Patients aged between 18-45 years, American Society of Anesthesiologists grade I-II undergoing elective lower-limb arthroscopic procedures were included. Variables including heart rate (HR), mean arterial pressure (MAP), stroke volume (SV), cardiac output (CO), systemic vascular resistance (SVR) and BIS were recorded continuously prior to induction and up to 3-minutes after. ResultsThe following relative haemodynamic changes were noted between baseline and 1-minute post-induction with propofol: CO +15.2%, HR +10.1%, SVR -22.9% and MAP -10.1%(p<0.001 for each parameter). There was a mean change of: HR -10.1%, CO -14% and MAP -18.0%(p<0.001 for each parameter) between baseline and 3-minutes post-induction. Median change of BIS was -61.7%(p<0.001) between baseline and 3-minutes post-induction. Significant, positive correlations noted between MAP and BIS at 30-seconds(r=0.60, p<0.001) and 1-minute post-induction (r=0.61, p<0.001).ConclusionOur study shows that healthy patients undergoing continuous minimally invasive orthopaedic surgery experience significant haemodynamic and BIS changes following induction of anaesthesia. Our findings highlight the importance of baseline cardiovascular and BIS monitoring as part
AU  - Vizcaychipi,MP
AU  - Hua
AU  - Loganathan
AU  - williams
AU  - Balogun-Lynch
AU  - Dob
DO  - 10.2174/1874321801711010075
EP  - 82
PY  - 2017///
SN  - 1874-3218
SP  - 75
TI  - Assessment of haemodynamic response to induction of general anaesthesia in healthy adult patients undergoing elective orthopaedic surgery by using a continuous non-invasive cardiovascular monitoring
T2  - Open Anesthesiology Journal
UR  - http://dx.doi.org/10.2174/1874321801711010075
UR  - http://hdl.handle.net/10044/1/42554
VL  - 11
ER  -
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