In this section
Anaesthesia makes up the largest hospital speciality and has a huge role to play in nearly every aspect of any hospital from operating theatres to accident and emergency, to the labour ward, and to intensive care. Our research ranges from basic molecular research into mechanisms of anaesthesia to investigating the clinical impact of novel anaesthetic agents.
Our research covers the entirety of patient’s perioperative journey and through this, we aim to deliver the greatest impact. The section has been pioneering in the development of novel technologies to facilitate the delivery of anaesthetic agents and has also made pivotal in-roads into the mechanism of action of anaesthetic agents and their wider application to other diseases (such as their protective roles in brain injury and in cancer).
@article{Wu,
author = {Wu, X and Cui, F and Zhang, C and Meng, Z and Wang, D and Ma, J and Wang, G and Zhu, S and Ma, D},
journal = {Anesthesiology},
title = {Low-dose dexmedetomidine improves sleep quality pattern in elderly patients after noncardiac surgery in the intensive care unit: a pilot randomized controlled trial},
url = {http://hdl.handle.net/10044/1/43872},
}
TY - JOUR
AB - Background: It has been shown that dexmedetomidine sedation can improve sleep architecture in mechanically ventilated patients. We hypothesized that low-dose dexmedetomidine infusion could also improve sleep architecture in non-mechanically ventilated elderly patients in the Intensive Care Unit (ICU) after surgery. Methods: This was a randomized, double-blind, placebo-controlled, parallel-arm pilot trial. Seventy-six patients of 65 years or older who were admitted to the ICU after non-cardiac surgery and did not require mechanical ventilation were randomized to receive dexmedetomidine (continuous infusion at a rate of 0.1 μg kg-1 h-1, n = 38) or placebo (n = 38) for 15 hours, i.e., from 5:00 PM on the day of surgery until 8:00 AM on the first day after surgery. Polysomnogram was monitored during the period of study drug infusion. The primary endpoint was the percentage of stage 2 non-rapid eye movement (stage N2) sleep. Results: Complete polysomnogram recordings were obtained in 61 patients (30 in the placebo group and 31 in the dexmedetomidine group). Compared with placebo, dexmedetomidine infusion significantly increased the percentage of stage N2 sleep (mean difference , 95% confidence interval -, P = ); it also significantly prolonged the total sleep time, decreased the percentage of stage N1 sleep, and increased the sleep efficiency. However, the incidence of hypotension of all enrolled patients were significantly higher in the dexmedetomidine group than in the placebo group (39.5% [15/38] vs 13.2% [5/38], P = 0.009). Conclusions: In non-mechanically ventilated elderly patients who were admitted to ICU after non-cardiac surgery, the prophylactic low-dose dexmedetomidine infusion may improve sleep architecture but increases hypotension.
AU - Wu,X
AU - Cui,F
AU - Zhang,C
AU - Meng,Z
AU - Wang,D
AU - Ma,J
AU - Wang,G
AU - Zhu,S
AU - Ma,D
SN - 1528-1175
TI - Low-dose dexmedetomidine improves sleep quality pattern in elderly patients after noncardiac surgery in the intensive care unit: a pilot randomized controlled trial
T2 - Anesthesiology
UR - http://hdl.handle.net/10044/1/43872
ER -