Anaesthesia makes up the largest hospital speciality and has a huge role to play in nearly every aspect of any hospital from operating theatres to accident and emergency, to the labour ward, and to intensive care. Our research ranges from basic molecular research into mechanisms of anaesthesia to investigating the clinical impact of novel anaesthetic agents.
Our research covers the entirety of patient’s perioperative journey and through this, we aim to deliver the greatest impact. The section has been pioneering in the development of novel technologies to facilitate the delivery of anaesthetic agents and has also made pivotal in-roads into the mechanism of action of anaesthetic agents and their wider application to other diseases (such as their protective roles in brain injury and in cancer).
Research themes:
- Anaesthesia mechanisms and effects
- Brain and neuroprotection
- Cardiothoracic anaesthesia and transplantation
Results
- Showing results for:
- Reset all filters
Search results
-
Journal articleVizcaychipi M, Grover S, Zhuang L, et al.,
Xenon preconditioning attenuates cognitive decline after orthopaedic surgery under general anaesthesia in mice
, Anesthesia & Analgesia -
Journal articlePotapov E, Meyer D, Swaminathan M, et al., 2011,
Inhaled nitric oxide after left ventricular assist device implantation: A prospective, randomized, double-blind, multicenter, placebo-controlled trial
, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 30, Pages: 870-878, ISSN: 1053-2498- Author Web Link
- Cite
- Citations: 76
-
Journal articleBertok S, Wilson MR, Dorr AD, et al., 2011,
Characterization of TNF receptor subtype expression and signaling on pulmonary endothelial cells in mice
, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 300, Pages: L781-L789, ISSN: 1040-0605- Author Web Link
- Cite
- Citations: 22
-
Journal articleVizcaychipi MP, Xu L, Barreto GE, et al., 2011,
Heat Shock Protein 72 Overexpression Prevents Early Postoperative Memory Decline after Orthopedic Surgery under General Anesthesia in Mice
, ANESTHESIOLOGY, Vol: 114, Pages: 891-900, ISSN: 0003-3022- Author Web Link
- Open Access Link
- Cite
- Citations: 36
-
Journal articleZhang L, Huang H, Cheng J, et al., 2011,
Pre-treatment with isoflurane ameliorates renal ischemic–reperfusion injury in mice
, Life Sciences, Vol: 88, Pages: 1102 - 1107-1102 - 1107, ISSN: 0024-3205 -
Journal articlePac-Soo C, Lloyd DG, Vizcaychipi MP, et al., 2011,
Statins: The Role in the Treatment and Prevention of Alzheimer's Neurodegeneration
, JOURNAL OF ALZHEIMERS DISEASE, Vol: 27, Pages: 1-10, ISSN: 1387-2877- Author Web Link
- Cite
- Citations: 37
-
Journal articleGu J, Sun P, Zhao H, et al., 2011,
Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice
, CRITICAL CARE, Vol: 15, ISSN: 1466-609X- Author Web Link
- Cite
- Citations: 204
-
Conference paperBanks P, Franks NP, 2011,
The NMDA receptor glycine site mediates xenon neuroprotection against hypoxic/ischemic injury
, 25th International Symposium on Cerebral Blood Flow, Metabolism & Function, Barcelona -
Journal articleWan Y, Xu J, Meng F, et al., 2010,
Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice
, CRITICAL CARE MEDICINE, Vol: 38, Pages: 2190-2198, ISSN: 0090-3493- Author Web Link
- Cite
- Citations: 124
-
Journal articleDickinson R, Franks NP, 2010,
Bench-to-bedside review: molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection
, Critical Care, Vol: 14, ISSN: 1364-8535In the past decade there has been a resurgence of interest in the clinical use of inert gases. In the present paper we review the use of inert gases as anesthetics and neuroprotectants, with particular attention to the clinical use of xenon. We discuss recent advances in understanding the molecular pharmacology of xenon and we highlight specific pharmacological targets that may mediate its actions as an anesthetic and neuroprotectant. We summarize recent in vitro and in vivo studies on the actions of helium and the other inert gases, and discuss their potential to be used as neuroprotective agents.
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.