Patient with anaesthesiaAnaesthesia makes up the largest hospital speciality and has a huge role to play in nearly every aspect of any hospital from operating theatres to accident and emergency, to the labour ward, and to intensive care. Our research ranges from basic molecular research into mechanisms of anaesthesia to investigating the clinical impact of novel anaesthetic agents. 

Our research covers the entirety of patient’s perioperative journey and through this, we aim to deliver the greatest impact. The section has been pioneering in the development of novel technologies to facilitate the delivery of anaesthetic agents and has also made pivotal in-roads into the mechanism of action of anaesthetic agents and their wider application to other diseases (such as their protective roles in brain injury and in cancer).

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  • Conference paper
    Fletcher M, Takata M, Marczin N, 2008,

    INHIBITORS OF GLUTATHIONE-S-TRANSFERASE INDUCE CELL DEATH IN LUNG EPITHELIAL CELLS

    , Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A144-A144, ISSN: 0040-6376
  • Journal article
    Farkasfalvi K, Stagg MA, Coppen SR, Siedlecka U, Lee J, Soppa GK, Marczin N, Szokodi I, Yacoub MH, Terracciano CMNet al., 2007,

    Direct effects of apelin on cardiomyocyte contractility and electrophysiology

    , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 357, Pages: 889-895, ISSN: 0006-291X
  • Journal article
    Wan YJ, Xu J, Ma DQ, Zeng YM, Cibelli M, Maze Met al., 2007,

    Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus

    , Anesthesiology, Vol: 106, Pages: 436-443, ISSN: 0003-3022
  • Journal article
    Andres-Enguix I, Caley A, Yustos R, Schumacher M A, Spanu P D, Dickinson R, Maze M, Franks N Pet al., 2007,

    Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channelfrom Lymnaea stagnalis

    , Journal of Biological Chemistry, Vol: 282, Pages: 20977-20990, ISSN: 0021-9258
  • Journal article
    Dickinson R, Peterson B, Banks P, Simillis C, Martin JC, Valenzuela CA, Maze M, Franks NPet al., 2007,

    Competitive Inhibition at the Glycine Site of the NMDA Receptor by the Anesthetics Xenon and Isoflurane: Evidence from Molecular Modeling and Electrophysiology

    , Anesthesiology, Vol: 107, Pages: 756-767
  • Journal article
    Ma DQ, Hossain M, Pettet GKJ, Luo Y, Lim T, Akimov S, Sanders RD, Franks NP, Maze Met al., 2006,

    Xenon preconditioning reduces brain damage from neonatal asphyxia in rats

    , JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 26, Pages: 199-208, ISSN: 0271-678X
  • Journal article
    Sanders RD, Ma D, Maze M, 2005,

    Anaesthesia induced neuroprotection.

    , Best Pract Res Clin Anaesthesiol, Vol: 19, Pages: 461-474, ISSN: 1753-3740

    Anaesthetic agents display remarkable neuroprotective potential; here, we describe the evidence supporting its use and highlight areas for future development of the field. In particular the application of isoflurane and/or xenon as inhalational neuroprotectants is advocated and evidence for the neuroprotection provided by barbiturates and suppression of cerebral metabolic rate is discussed.
  • Journal article
    Sanders RD, Patel N, Hossain M, Ma D, Maze Met al., 2005,

    Isoflurane exerts antinociceptive and hypnotic properties at all ages in Fischer rats

    , BRITISH JOURNAL OF ANAESTHESIA, Vol: 95, Pages: 393-399, ISSN: 0007-0912
  • Journal article
    Ma DQ, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze Met al., 2005,

    Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia

    , ANNALS OF NEUROLOGY, Vol: 58, Pages: 182-193, ISSN: 0364-5134
  • Journal article
    White IL, Franks NP, Dickinson R, 2005,

    Effects of isoflurane and xenon on Ba<SUP>2+</SUP>-currents mediated by N-type calcium channels

    , BRITISH JOURNAL OF ANAESTHESIA, Vol: 94, Pages: 784-790, ISSN: 0007-0912

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