Critical care wardCritical care involves the care of the sickest patients in the hospital. Critically ill patients have usually been through a significant insult to their body (such as trauma, infection, burn) and have developed organ failure and require life-support. Critical Care is the largest theme bringing together clinicians and scientists from diverse backgrounds and includes collaborative research from hospitals throughout north-west London. Investigations range from evaluating biological mechanisms of organ failure through to the development of innovative technologies which allow the short-term and long-term support and recovery of organs. 

Many people are exposed to the environment of an Intensive care unit (ICU) either personally or through a family member. It is often a life-changing event and our work aims to reduce this impact facilitating post-ICU recovery.

Research themes:

Citation

BibTex format

@article{Rippon:2008:10.1513/pats.200801-008AW,
author = {Rippon, HJ and Lane, S and Qin, M and Ismail, N-S and Wilson, MR and Takata, M and Bishop, AE},
doi = {10.1513/pats.200801-008AW},
journal = {Proc Am Thorac Soc},
pages = {717--722},
title = {Embryonic stem cells as a source of pulmonary epithelium in vitro and in vivo.},
url = {http://dx.doi.org/10.1513/pats.200801-008AW},
volume = {5},
year = {2008}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Embryonic stem cells (ESCs) derived from the preimplantation blastocyst are pluripotent and capable of indefinite expansion in vitro. As such, they present a cell source to derive a potentially inexhaustible supply of pulmonary cells and tissue. ESC-derived pulmonary epithelium could be used for in vitro cell or tissue models or, in the future, implanted into the damaged or diseased lung to effect repair. Efforts to date have largely focused on obtaining distal lung epithelial phenotypes from ESCs, notably alveolar epithelium. Several disparate methods have been developed to enhance differentiation of ESCs into pulmonary epithelial lineages; these are broadly based on recapitulating developmental signaling events, mimicking the physical environment, or forcibly reprogramming the ESC nucleus. Early findings of our preclinical experiments implanting differentiated ESCs into the injured lung are also described here. Future efforts will focus on maximizing ESC differentiation efficiency and yield of the target phenotype, as well as characterizing the function of derived cells in vivo and in vitro.
AU  - Rippon,HJ
AU  - Lane,S
AU  - Qin,M
AU  - Ismail,N-S
AU  - Wilson,MR
AU  - Takata,M
AU  - Bishop,AE
DO  - 10.1513/pats.200801-008AW
EP  - 722
PY  - 2008///
SN  - 1546-3222
SP  - 717
TI  - Embryonic stem cells as a source of pulmonary epithelium in vitro and in vivo.
T2  - Proc Am Thorac Soc
UR  - http://dx.doi.org/10.1513/pats.200801-008AW
UR  - https://www.ncbi.nlm.nih.gov/pubmed/18684724
VL  - 5
ER  -
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