Critical care wardCritical care involves the care of the sickest patients in the hospital. Critically ill patients have usually been through a significant insult to their body (such as trauma, infection, burn) and have developed organ failure and require life-support. Critical Care is the largest theme bringing together clinicians and scientists from diverse backgrounds and includes collaborative research from hospitals throughout north-west London. Investigations range from evaluating biological mechanisms of organ failure through to the development of innovative technologies which allow the short-term and long-term support and recovery of organs. 

Many people are exposed to the environment of an Intensive care unit (ICU) either personally or through a family member. It is often a life-changing event and our work aims to reduce this impact facilitating post-ICU recovery.

Research themes:

Citation

BibTex format

@article{Blackbeard:2012:10.1002/j.1532-2149.2012.00140.x,
author = {Blackbeard, J and Wallace, VC and O'Dea, KP and Hasnie, F and Segerdahl, A and Pheby, T and Field, MJ and Takata, M and Rice, AS},
doi = {10.1002/j.1532-2149.2012.00140.x},
journal = {Eur.J Pain},
pages = {1357--1367},
title = {The correlation between pain-related behaviour and spinal microgliosis in four distinct models of peripheral neuropathy},
url = {http://dx.doi.org/10.1002/j.1532-2149.2012.00140.x},
volume = {16},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Peripheral nerve injury is associated with a spinal microglial response that has been correlated with the development of behaviours reflective of neuropathic pain. METHODS: To examine whether this phenomenon is generalizable to neuropathic pain of non-traumatic aetiology, this study investigated the association between spinal microgliosis and behavioural measures of neuropathic hypersensitivity and pain-related anxiety behaviour in four distinct rat models of peripheral neuropathic pain. These were traumatic neuropathy [L5 spinal nerve transection (SNT)], HIV-related neuropathies (either treatment with the antiretroviral drug Zalcitabine (ddC) or combination of perineural exposure to the HIV-gp120 protein and ddC treatment) and varicella zoster virus (VZV) infection. RESULTS AND CONCLUSION: Persistent mechanical hypersensitivity developed in all 'neuropathic' rats. However, spinal microgliosis, as measured by increased CD11b/c immunohistochemical staining and increased numbers of cells expressing CD11b measured by flow cytometry, was evident in the SNT and to a lesser extent in the HIV neuropathy models but not the VZV model. These results suggest that behavioural hypersensitivity and thigmotaxis can only be linked to a microglial response in certain models of neuropathy
AU  - Blackbeard,J
AU  - Wallace,VC
AU  - O'Dea,KP
AU  - Hasnie,F
AU  - Segerdahl,A
AU  - Pheby,T
AU  - Field,MJ
AU  - Takata,M
AU  - Rice,AS
DO  - 10.1002/j.1532-2149.2012.00140.x
EP  - 1367
PY  - 2012///
SP  - 1357
TI  - The correlation between pain-related behaviour and spinal microgliosis in four distinct models of peripheral neuropathy
T2  - Eur.J Pain
UR  - http://dx.doi.org/10.1002/j.1532-2149.2012.00140.x
UR  - pm:22467279
VL  - 16
ER  -
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