Critical care involves the care of the sickest patients in the hospital. Critically ill patients have usually been through a significant insult to their body (such as trauma, infection, burn) and have developed organ failure and require life-support. Critical Care is the largest theme bringing together clinicians and scientists from diverse backgrounds and includes collaborative research from hospitals throughout north-west London. Investigations range from evaluating biological mechanisms of organ failure through to the development of innovative technologies which allow the short-term and long-term support and recovery of organs.
Many people are exposed to the environment of an Intensive care unit (ICU) either personally or through a family member. It is often a life-changing event and our work aims to reduce this impact facilitating post-ICU recovery.
Research themes:
- Acute Respiratory Distress Syndrome (ARDS)
- Burn injury
- Extracorporeal life support
- Functional outcomes and health service research
- Sepsis
Results
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Journal articleGhosh S, Wilson MR, Choudhury S, et al., 2005,
Effects of inhaled carbon monoxide on acute lung injury in mice
, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 288, Pages: L1003-L1009, ISSN: 1040-0605- Author Web Link
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- Citations: 34
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Journal articleWilson MR, Choudhury S, Takata M, 2005,
Pulmonary inflammation induced by high-stretch ventilation is mediated by tumor necrosis factor signaling in mice
, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 288, Pages: L599-L607, ISSN: 1040-0605- Author Web Link
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- Citations: 80
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Journal articleChoudhury S, Wilson MR, Goddard ME, et al., 2004,
Mechanisms of early pulmonary neutrophil sequestration in ventilator-induced lung injury in mice
, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 287, Pages: L902-L910, ISSN: 1040-0605- Author Web Link
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- Citations: 79
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Journal articleWilson MR, Choudhury S, Goddard ME, et al., 2003,
High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury
, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 95, Pages: 1385-1393, ISSN: 8750-7587- Author Web Link
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- Citations: 166
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