Critical care involves the care of the sickest patients in the hospital. Critically ill patients have usually been through a significant insult to their body (such as trauma, infection, burn) and have developed organ failure and require life-support. Critical Care is the largest theme bringing together clinicians and scientists from diverse backgrounds and includes collaborative research from hospitals throughout north-west London. Investigations range from evaluating biological mechanisms of organ failure through to the development of innovative technologies which allow the short-term and long-term support and recovery of organs.
Many people are exposed to the environment of an Intensive care unit (ICU) either personally or through a family member. It is often a life-changing event and our work aims to reduce this impact facilitating post-ICU recovery.
Research themes:
- Acute Respiratory Distress Syndrome (ARDS)
- Burn injury
- Extracorporeal life support
- Functional outcomes and health service research
- Sepsis
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Journal articleBertok S, Wilson MR, Dorr AD, et al., 2011,
Characterization of TNF receptor subtype expression and signaling on pulmonary endothelial cells in mice
, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 300, Pages: L781-L789, ISSN: 1040-0605- Author Web Link
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- Citations: 22
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Journal articleCampbell L, Shrosbree J, Ibrahim F, et al., 2011,
Late HIV diagnosis is a major risk factor for intensive care unit (ICU) admission in HIV-positive patients
, HIV MEDICINE, Vol: 12, Pages: 52-52, ISSN: 1464-2662 -
Journal articleTatham K, Hughes-Roberts Y, Davies S, et al., 2010,
Peripartum cardiac chest pain and troponin rise
, INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA, Vol: 19, Pages: 453-455, ISSN: 0959-289X- Author Web Link
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- Citations: 3
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Journal articleWilson MR, O'Dea KP, Dorr AD, et al., 2010,
Efficacy and safety of inhaled carbon monoxide during pulmonary inflammation in mice
, PLOS One, Vol: 5, ISSN: 1932-6203 -
Journal articleGrover S, Vizcaychipi MP, Ma D,
Anaesthetic management of patients with acute spinal injury
, Anesthesiology Research and Practice -
Journal articleVizcaychipi MP, Keays R, 2010,
Anaesthesia and intensive care in HIV patients
, http://www.sciencedirect.com/science/journal/14720299, Vol: 11, Pages: 37-41HIV is a blood-borne viral infection that has implications for anaesthesia and intensive care. HIV was initially described in 1981 and it was associated with very high mortality when patients were admitted to intensive care. There have been several advances in the management of HIV patients over the past decades. Antiretroviral therapy is targeted to individuals with high viral load and or symptoms apart from CD4 count. This approach not only helps to keep patients free of symptoms for a long period of time but also contributes to better survival duration and outcome when patients are admitted to intensive care. It has been a challenge to anaesthetize this group of patients because drug interaction is a potential risk and regional anaesthesia may be potentially hazardous if a cautious and exhaustive neurological examination is not performed. New generations of drugs may be more effective and, hopefully, have fewer side effects. There will be more patients in long-term remission from the disease but its implications are still unclear. This disease is no longer rare and clinicians need to have a working knowledge of its presentation and management.
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Journal articleGordon AC, Russell JA, Walley KR, et al., 2010,
The effects of vasopressin on acute kidney injury in septic shock
, INTENSIVE CARE MEDICINE, Vol: 36, Pages: 83-91, ISSN: 0342-4642- Author Web Link
- Open Access Link
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- Citations: 159
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Journal articleHandy JM, Scott AJ, Cross AM, et al., 2010,
HLA-DR expression and differential trafficking of monocyte subsets following low to intermediate risk surgery
, ANAESTHESIA, Vol: 65, Pages: 27-35, ISSN: 0003-2409- Author Web Link
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- Citations: 16
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Conference paperFletcher M, Boshier P, Smolenski RT, et al., 2009,
MOLECULAR MECHANISMS OF LUNG EPITHELIAL CELL INJURY INDUCED BY INHIBITION OF GLUTATHIONE-<i>S</i>-TRANSFERASE
, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A38-A39, ISSN: 0040-6376 -
Journal articleWilson MR, O'Dea KP, Zhang D, et al., 2009,
Role of Lung-marginated Monocytes in an <i>In Vivo</i> Mouse Model of Ventilator-induced Lung Injury
, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, Pages: 914-922, ISSN: 1073-449X- Author Web Link
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- Citations: 64
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