Process Optimisation for Advanced Pharmaceutical Manufacturing in Industry 4.0
Abstract
Continuous Pharmaceutical Manufacturing (CPM) emerges as a ground-breaking technology which can invigorate the global pharmaceutical industry by sustainably fostering its agility and the affordability of healthcare for large populations: advances in continuous organic synthesis routes which induce demonstrations of full (end-to-end) continuous pharmaceutical production and comparative economic analyses explicitly illustrate CPM advantages, thus attracting strong, sustained interest of global pharmaceutical corporations and authoritative regulatory bodies. Remarkable corporate investments in production-scale CPM facilities illustrate the value of this novel paradigm.
This lecture will focus on our successful applications of process systems engineering methodologies (process synthesis, modelling, simulation, deterministic and stochastic optimisation) towards evaluating technical efficiency, environmental impact and economic viability of several new continuous processes for manufacturing Active Pharmaceutical Ingredients (APIs) as well as biopharmaceutical products of high importance based on published flow synthesis precedents. Detailed process design, economic and environmental impact results will be presented.
Biography
Dr. Dimitrios Gerogiorgis is a Senior Lecturer (Associate Professor) in Chemical Engineering and a recent Royal Academy of Engineering (RAEng) Industrial Fellow at the Institute for Materials and Processes (School of Engineering, University of Edinburgh), focusing on process systems modelling, design and optimisation. He holds a Diploma in Chemical Engineering (Aristotle University of Thessaloniki, Greece), an MSc in Electrical and Computer Engineering and a PhD in Chemical Engineering (Carnegie Mellon University). His research portfolio includes the model-based development of the Alcoa ARP carbothermic aluminium reactor (Pittsburgh, USA), the NTUA vertical perlite expansion furnace (Athens, GR), the optimisation of investment planning for efficient polygeneration energy systems (Imperial College London), the systematic methodology for interval arithmetic evaluation of candidate flowsheets, the first comparative economic evaluation of batch vs. continuous pharmaceutical manufacturing strategies (Novartis-MIT Center for Continuous Manufacturing), and significant advances in systematic multi-objective dynamic optimisation of beer fermentation (with Molson Coors UK). He currently holds a Royal Society (RS) Short Industry Fellowship (hosted by GSK) and has successfully supervised 5 completed PhD projects, with 7 more under way, has advised 15 completed MSc/MEng projects, and has authored over 80 peer-reviewed publications in journals and book series. He has been recognized with the Academy of Athens L. Mousoulos Research Excellence Prize (2015), a High Commendation for the IChemE Global Food and Drink Award (2017), the Best Oral Presentation Award of the 3rd CSIRO International CFD Conference (Australia), and an RSE Scottish Crucible membership (2015). He has delivered invited lectures at McGill University (Canada), Univ. Rovira i Virgili (Spain), the Max Planck Institute (Potsdam, Germany) and the Universities of Maribor (Slovenia) and Budapest/BUTE (Hungary). The course on Oil & Gas Systems Engineering he has developed in collaboration with Atkins (Aberdeen) has been shortlisted for the IChemE Global Education & Training Award (2015).
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When: 21st Apr 2021 13:00 PM London
Topic: Sargent Centre Seminar Series – Dr Dimitrios Gerogiorgis, University of Edinburgh
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