Join us for the Winter Series

of the St Mary’s Infection & Immunity Seminars (hybrid)

Daniel Goncalves-Carneiro

Biography

Daniel Gonçalves-Carneiro received his PhD from the University of Birmingham, UK for his work on measles virus infection under the guidance of Dr Dalan Bailey. He later moved to the Rockefeller University, in New York, where he studied how certain RNA viruses are sensed by the zinc finger antiviral protein (ZAP), inhibiting virus replication. He showed that while human ZAP specifically recognises CpG dinucleotides in virus RNA, zinc finger antiviral proteins from many species of birds have distinct binding preferences. By characterising RNA binding preferences of human ZAP, he engineered genomes of enterovirus A71 with enhanced sensitivity to ZAP to generate stably attenuated virus with vaccine potential. Daniel joined the department of infectious disease in 2022, where he is currently investigating how synonymous mutations in the genomes of viruses contribute to immune evasion.

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