An ad hoc Divison of Cancer Seminar hosted by Dr Olivier Pardo.
We are delighted to have Stefan Marciniak, Professor of Respiratory Science, Cambridge Institute for Medical Research and Hon Consultant in Respiratory Medicine, Cambridge University Hospitals, Stefan studied medicine at the University of Cambridge as part of the MB/PhD programme. He completed post-doctoral fellowships in New York and Cambridge before setting up his own group at the Cambridge Institute for Medical Research (CIMR). He is a respiratory physician in Cambridge specialising in pleural diseases. His lab focuses on the role of protein misfolding in rare diseases.
He will discuss challenges faced when attempting to use in vitro models to study mesothelioma, and how information gleaned from single cell technologies helps us to optimise our studies. The development of new mesothelioma organoids will be discussed, and their characterisation by genomic, transcriptomic, high-throughput drug screens, and whole genome CRISPR-Cas9 dependency screening will be presented. Novel approaches of intra-cellular drug delivery will be presented.