DOID weekly seminar series (hybrid)
join us for the next Guest Seminar in the Autumn/Winter series
Biography – Prof Ashraful Haque
Associate Professor Ash Haque studied Natural Sciences (& Pt II Biochemistry) at Cambridge University in the 1990’s, followed by a PhD in Salmonella pathogenesis with Prof Gordon Dougan at Imperial College, London. After post-doctoral research at the London School of Hygiene & Tropical Medicine, on immune responses during gram-negative bacterial infection, he moved to Australia in 2006. He currently leads an immunology lab at the University of Melbourne, Australia, and co-leads a Research Theme on Bacterial & Parasitic Infections at the Peter Doherty Institute for Infection and Immunity. He has pursued a career understanding T cell responses during infection with malaria parasites. Over the last decade, his team has utilised single-cell genomics and spatial transcriptomics to determine how CD4+ T cells, and more recently, B cells, differentiate and respond during infection. He likes science, but prefers electric guitars……..
Abstract
Immunity to blood-stage malaria parasites depends on antibodies produced as a result of the activation, differentiation and interactions between CD4+ T cells and B cells. Using clinically relevant mouse models of infection, in conjunction with scRNAseq, scATACseq, spatial transcriptomics at single-cell resolution, and computational modelling, we have determined how these cells exhibit phenotypic diversification. In addition we describe how the use of TCR transgenic T cells and CRISPR/Cas9 gene disruption has elucidated novel mechanisms controlling T cell differentiation.
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G34 Lecture Theatre, Mezzanine Level, Sir Alexander Fleming Building (no swipe access required)
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Meeting ID: 349 412 304 38
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for general enquiries contact @Mallu, Yasmin
