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From techniques such as microscopy and FACS analysis, we know that many cell populations harbour heterogeneity in morphology and protein expression. With the advent of high throughput single cell RNA-sequencing, we can now quantify transcriptomic cell-to-cell variation. I will discuss technical advances and biological insights into understanding cellular heterogeneity in T cells and ES cells using single cell RNA-sequencing.
I will give an introduction to the ‘Human Cell Atlas’ – a project to create comprehensive reference maps of all human cells—the fundamental units of life—as a basis for both understanding human health and diagnosing, monitoring, and treating disease
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Sarah is the Head of Cellular Genetics at the Wellcome Trust Sanger Institute and is interested in global principles of protein interactions and gene expression. In particular, her research now focuses on genomics and immunity. She is one of the founders of the ‘Human Cell Atlas’, an ambitious project to map all the cells in the human body.
Sarah did her PhD at the MRC Laboratory of Molecular Biology, Cambridge, UK and was a Beit Memorial Fellow at University College London. She started a group at the MRC Laboratory of Molecular Biology in 2001. In 2013, she moved to the Wellcome Genome Campus in Hinxton, Cambridge, where her group was joint between the EMBL-European Bioinformatics Institute and the WT Sanger Institute. Sarah is an EMBO member and fellow of the Academy of Medical Sciences, and her work has been recognized by a number of prizes, including the Lister Prize, Biochemical Society Colworth Medal, Royal Society Crick Lecture and EMBO Gold Medal.
You can register for the event here.
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