BibTex format
@article{Kleiner:2008,
author = {Kleiner, A and Flohr, C and Weiland, S and Weinmayr, G and Büchele, G and Rzehak, P and Björkstén, B and Bråbäck, L and Brunekreef, B and Clausen, M and Cookson, W and Von, Mutius E and Strachan, D and Williams, H},
journal = {Allergo Journal},
pages = {79--81},
title = {International variation in prevalence of flexural eczema and atopic sensitization. Results from phase two of the International Study of Asthma and Allergies in Childhood (ISAAC Phase Two)},
volume = {17},
year = {2008}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Background: There is debate in the dermatology literature whether flexural eczema in childhood is really an atopic disease. After a systematic literature review, Flohr et al. concluded that the prevalence of atopy among subjects with flexural eczema varies greatly between study populations and is on average higher in hospital than in community settings. The association between flexural eczema in childhood and atopy in a wide range of study centers was investigated in phase two of the ISAAC study. Detailed results have already been published in the Journal of Allergy and Clinical Immunology. Methods: ISAAC Phase Two is a multicenter cross-sectional study, and 27 centers from 18 countries worldwide contributed data to the presented analysis. The prevalence of symptoms of flexural eczema was determined by parental questionnaire in eight-to twelve-year-old children (approximately 1,000 per center). In addition, a skin examination for flexural eczema was carried out in 30,031 children and a skin prick test for atopy was performed, using six common allergens: Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, Alternaria tenuis, tree and grass pollen. Some centers tested additional allergens of local relevance. A skin prick test was rated as positive, if the reaction minus the negative control was ≥ 3 mm, and a child was defined as atopic, if it had at least one positive skin prick test. Results: The prevalence of flexural eczema from skin examination shows a high variability and ranges from 0.4% in Kintampo, Ghana, to 14.2% in Östersund, Sweden. The prevalence of atopic flexural eczema (flexural eczema in combination with a positive skin prick test) varies from 0% in Kintampo, Ghana, and Ramallah, West Bank, to 7.0% in Östersund, Sweden. Nonatopic flexural eczema was most common (6.9%) in Östersund, Sweden, and least common (0.4%) in Kintampo, Ghana, and Cartagena, Spain. The proportion of atopic children among children with eczema varies lar
AU - Kleiner,A
AU - Flohr,C
AU - Weiland,S
AU - Weinmayr,G
AU - Büchele,G
AU - Rzehak,P
AU - Björkstén,B
AU - Bråbäck,L
AU - Brunekreef,B
AU - Clausen,M
AU - Cookson,W
AU - Von,Mutius E
AU - Strachan,D
AU - Williams,H
EP - 81
PY - 2008///
SN - 0941-8849
SP - 79
TI - International variation in prevalence of flexural eczema and atopic sensitization. Results from phase two of the International Study of Asthma and Allergies in Childhood (ISAAC Phase Two)
T2 - Allergo Journal
VL - 17
ER -