BibTex format
@article{Lord:2024:10.1186/s12979-023-00406-z,
author = {Lord, JM and Veenith, T and Sullivan, J and Sharma-Oates, A and Richter, AG and Greening, NJ and McAuley, HJC and Evans, RA and Moss, P and Moore, SC and Turtle, L and Gautam, N and Gilani, A and Bajaj, M and Wain, LV and Brightling, C and Raman, B and Marks, M and Singapuri, A and Elneima, O and Openshaw, PJM and Duggal, NA and PHOSP-COVID, Study collaborative group and ISARIC4C, investigators},
doi = {10.1186/s12979-023-00406-z},
journal = {Immunity and Ageing},
title = {Accelarated immune ageing is associated with COVID-19 disease severity},
url = {http://dx.doi.org/10.1186/s12979-023-00406-z},
volume = {21},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND: The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent immunesenescence and acute disease severity, we determined the immune phenotype of COVID-19 survivors and non-infected controls. RESULTS: We performed detailed immune phenotyping of peripheral blood mononuclear cells isolated from 103 COVID-19 survivors 3-5 months post recovery who were classified as having had severe (n = 56; age 53.12 ± 11.30 years), moderate (n = 32; age 52.28 ± 11.43 years) or mild (n = 15; age 49.67 ± 7.30 years) disease and compared with age and sex-matched healthy adults (n = 59; age 50.49 ± 10.68 years). We assessed a broad range of immune cell phenotypes to generate a composite score, IMM-AGE, to determine the degree of immune senescence. We found increased immunesenescence features in severe COVID-19 survivors compared to controls including: a reduced frequency and number of naïve CD4 and CD8 T cells (p < 0.0001); increased frequency of EMRA CD4 (p < 0.003) and CD8 T cells (p < 0.001); a higher frequency (p < 0.0001) and absolute numbers (p < 0.001) of CD28-ve CD57+ve senescent CD4 and CD8 T cells; higher frequency (p < 0.003) and absolute numbers (p < 0.02) of PD-1 expressing exhausted CD8 T cells; a two-fold increase in Th17 polarisation (p < 0.0001); higher frequency of memory B cells (p < 0.001) and increased frequency (p < 0.0001) and numbers (p < 0.001) of CD57+ve senescent NK cells. As a result, the IMM-AGE score was significantly higher in severe COVID-19 sur
AU - Lord,JM
AU - Veenith,T
AU - Sullivan,J
AU - Sharma-Oates,A
AU - Richter,AG
AU - Greening,NJ
AU - McAuley,HJC
AU - Evans,RA
AU - Moss,P
AU - Moore,SC
AU - Turtle,L
AU - Gautam,N
AU - Gilani,A
AU - Bajaj,M
AU - Wain,LV
AU - Brightling,C
AU - Raman,B
AU - Marks,M
AU - Singapuri,A
AU - Elneima,O
AU - Openshaw,PJM
AU - Duggal,NA
AU - PHOSP-COVID,Study collaborative group
AU - ISARIC4C,investigators
DO - 10.1186/s12979-023-00406-z
PY - 2024///
SN - 1742-4933
TI - Accelarated immune ageing is associated with COVID-19 disease severity
T2 - Immunity and Ageing
UR - http://dx.doi.org/10.1186/s12979-023-00406-z
UR - https://www.ncbi.nlm.nih.gov/pubmed/38212801
UR - https://immunityageing.biomedcentral.com/articles/10.1186/s12979-023-00406-z
UR - http://hdl.handle.net/10044/1/109401
VL - 21
ER -