BibTex format
@article{Baltas:2024:jacamr/dlae010,
author = {Baltas, I and Kavallieros, K and Konstantinou, G and Koutoumanou, E and Gibani, MM and Gilchrist, M and Davies, F and Pavlu, J},
doi = {jacamr/dlae010},
journal = {JAC Antimicrob Resist},
title = {The effect of ciprofloxacin prophylaxis during haematopoietic cell transplantation on infection episodes, exposure to treatment antimicrobials and antimicrobial resistance: a single-centre retrospective cohort study.},
url = {http://dx.doi.org/10.1093/jacamr/dlae010},
volume = {6},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - OBJECTIVES: Fluroquinolone prophylaxis during haematopoietic cell transplantation (HCT) remains contentious. We aimed to determine its effectiveness and association with exposure to treatment antimicrobials and antimicrobial resistance. METHODS: All admission episodes for HCT (N=400, 372 unique patients) in a tertiary centre between January 2020 and December 2022 were studied. Allogeneic HCT (allo-HCT) recipients received prophylaxis with ciprofloxacin during chemotherapy-induced neutropenia, while autologous HCT (auto-HCT) recipients did not. RESULTS: Allo-HCT was performed for 43.3% (173/400) of patients, auto-HCT for 56.7% (227/400). Allo-HCT was associated with an average of 1.01 fewer infection episodes per 100 admission days (95% CI 0.62-1.40, P<0.001) compared with auto-HCT. In allo-HCT, the total exposure to all antimicrobials was higher [+24.8 days of therapy (DOT)/100 admission days, P<0.001], as was exposure to ciprofloxacin (+40.5 DOT/100 admission days, P<0.001). By contrast, exposure to meropenem (-4.5 DOT/100 admission days, P=0.02), piperacillin/tazobactam (-5.2 DOT/100 admission days, P<0.001), aminoglycosides (-4.5 DOT/100 admission days, P<0.001) and glycopeptides (-6.4 DOT/100 admission days, P<0.001) was reduced. Enterobacteriaceae isolated during allo-HCT were more resistant to ciprofloxacin (65.5%, 19/29 versus 6.1%, 2/33, P<0001), ceftriaxone (65.5%, 19/29 versus 9.1%, 3/33, P<0.001), other antimicrobial classes. Vancomycin-resistant enterococci were more common in allo-HCT recipients (11%, 19/173 versus 0.9%, 2/227, P<0.001). Inpatient mortality during allo- and auto-HCT was 9.8% (17/173) and 0.4% (1/227). respectively (P<0.001). CONCLUSIONS: Ciprofloxacin prophylaxis in allo-HCT was associated with fewer infection episodes and reduced exposure to treatment antimicrobials. Mortality in auto-HCT remained low. A significant burden of antimicrobial resistance was detected in allo-HCT recipi
AU - Baltas,I
AU - Kavallieros,K
AU - Konstantinou,G
AU - Koutoumanou,E
AU - Gibani,MM
AU - Gilchrist,M
AU - Davies,F
AU - Pavlu,J
DO - jacamr/dlae010
PY - 2024///
TI - The effect of ciprofloxacin prophylaxis during haematopoietic cell transplantation on infection episodes, exposure to treatment antimicrobials and antimicrobial resistance: a single-centre retrospective cohort study.
T2 - JAC Antimicrob Resist
UR - http://dx.doi.org/10.1093/jacamr/dlae010
UR - https://www.ncbi.nlm.nih.gov/pubmed/38304723
VL - 6
ER -