BibTex format
@article{Budden:2024:10.1136/gutjnl-2023-330521,
author = {Budden, KF and Shukla, SD and Bowerman, KL and Vaughan, A and Gellatly, SL and Wood, DLA and Lachner, N and Idrees, S and Rehman, SF and Faiz, A and Patel, VK and Donovan, C and Alemao, CA and Shen, S and Amorim, N and Majumder, R and Vanka, KS and Mason, J and Haw, TJ and Tillet, B and Fricker, M and Keely, S and Hansbro, N and Belz, GT and Horvat, J and Ashhurst, T and van, Vreden C and McGuire, H and Fazekas, de St Groth B and King, NJC and Crossett, B and Cordwell, SJ and Bonaguro, L and Schultze, JL and Hamilton-Williams, EE and Mann, E and Forster, SC and Cooper, MA and Segal, LN and Chotirmall, SH and Collins, P and Bowman, R and Fong, KM and Yang, IA and Wark, PAB and Dennis, PG and Hugenholtz, P and Hansbro, PM},
doi = {10.1136/gutjnl-2023-330521},
journal = {Gut},
pages = {751--769},
title = {Faecal microbial transfer and complex carbohydrates mediate protection against COPD.},
url = {http://dx.doi.org/10.1136/gutjnl-2023-330521},
volume = {73},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a major cause of global illness and death, most commonly caused by cigarette smoke. The mechanisms of pathogenesis remain poorly understood, limiting the development of effective therapies. The gastrointestinal microbiome has been implicated in chronic lung diseases via the gut-lung axis, but its role is unclear. DESIGN: Using an in vivo mouse model of cigarette smoke (CS)-induced COPD and faecal microbial transfer (FMT), we characterised the faecal microbiota using metagenomics, proteomics and metabolomics. Findings were correlated with airway and systemic inflammation, lung and gut histopathology and lung function. Complex carbohydrates were assessed in mice using a high resistant starch diet, and in 16 patients with COPD using a randomised, double-blind, placebo-controlled pilot study of inulin supplementation. RESULTS: FMT alleviated hallmark features of COPD (inflammation, alveolar destruction, impaired lung function), gastrointestinal pathology and systemic immune changes. Protective effects were additive to smoking cessation, and transfer of CS-associated microbiota after antibiotic-induced microbiome depletion was sufficient to increase lung inflammation while suppressing colonic immunity in the absence of CS exposure. Disease features correlated with the relative abundance of Muribaculaceae, Desulfovibrionaceae and Lachnospiraceae family members. Proteomics and metabolomics identified downregulation of glucose and starch metabolism in CS-associated microbiota, and supplementation of mice or human patients with complex carbohydrates improved disease outcomes. CONCLUSION: The gut microbiome contributes to COPD pathogenesis and can be targeted therapeutically.
AU - Budden,KF
AU - Shukla,SD
AU - Bowerman,KL
AU - Vaughan,A
AU - Gellatly,SL
AU - Wood,DLA
AU - Lachner,N
AU - Idrees,S
AU - Rehman,SF
AU - Faiz,A
AU - Patel,VK
AU - Donovan,C
AU - Alemao,CA
AU - Shen,S
AU - Amorim,N
AU - Majumder,R
AU - Vanka,KS
AU - Mason,J
AU - Haw,TJ
AU - Tillet,B
AU - Fricker,M
AU - Keely,S
AU - Hansbro,N
AU - Belz,GT
AU - Horvat,J
AU - Ashhurst,T
AU - van,Vreden C
AU - McGuire,H
AU - Fazekas,de St Groth B
AU - King,NJC
AU - Crossett,B
AU - Cordwell,SJ
AU - Bonaguro,L
AU - Schultze,JL
AU - Hamilton-Williams,EE
AU - Mann,E
AU - Forster,SC
AU - Cooper,MA
AU - Segal,LN
AU - Chotirmall,SH
AU - Collins,P
AU - Bowman,R
AU - Fong,KM
AU - Yang,IA
AU - Wark,PAB
AU - Dennis,PG
AU - Hugenholtz,P
AU - Hansbro,PM
DO - 10.1136/gutjnl-2023-330521
EP - 769
PY - 2024///
SP - 751
TI - Faecal microbial transfer and complex carbohydrates mediate protection against COPD.
T2 - Gut
UR - http://dx.doi.org/10.1136/gutjnl-2023-330521
UR - https://www.ncbi.nlm.nih.gov/pubmed/38331563
VL - 73
ER -