@article{Versi:2024,
author = {Versi, A and Azim, A and Ivan, FX and Abdel-Aziz, M and Bates, S and Riley, J and Maitland-Van, der Zee A and Dahlen, S-E and Djukanovic, R and Chotirmall, S and Howarth, P and Zounemat, Kermani N and Chung, KF and Adcock, I},
journal = {European Respiratory Journal},
title = {Host-microbial interactions differ with age of asthma onset},
url = {https://erj.ersjournals.com/content/early/2024/07/04/13993003.00428-2024},
year = {2024}
}

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TY  - JOUR
AB  - Asthma is a heterogenous disease [1] and dichotomisation between childhood/early-onset (EO) and adult/late-onset (LO) disease [2] identified differences in lung function decline and response to anti-inflammatory therapies including biologics [3]. This suggests distinct inflammatory mechanisms underpin EO and LO asthma. In parallel, a relationship exists between airway neutrophilia and the airway microbiome [4, 5]. We postulate that differences in host-microbial interactions are associated with the age of asthma onset and would be maintained over time. Here, we applied a recently described machine learning framework, sparse canonical correlation analysis (Sparse-CCA) [6], to identify differences in host-microbial interactions in the airways of EO and LO asthma.
AU  - Versi,A
AU  - Azim,A
AU  - Ivan,FX
AU  - Abdel-Aziz,M
AU  - Bates,S
AU  - Riley,J
AU  - Maitland-Van,der Zee A
AU  - Dahlen,S-E
AU  - Djukanovic,R
AU  - Chotirmall,S
AU  - Howarth,P
AU  - Zounemat,Kermani N
AU  - Chung,KF
AU  - Adcock,I
PY  - 2024///
SN  - 0903-1936
TI  - Host-microbial interactions differ with age of asthma onset
T2  - European Respiratory Journal
UR  - https://erj.ersjournals.com/content/early/2024/07/04/13993003.00428-2024
UR  - http://hdl.handle.net/10044/1/112971
ER  - 

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