In this section
@article{Lira-Junior:2024:10.1002/JPER.23-0676,
author = {Lira-Junior, R and Aogáin, MM and Crncalo, E and Ekberg, NR and Chotirmall, SH and Pettersson, S and Gustafsson, A and Brismar, K and Bostanci, N},
doi = {10.1002/JPER.23-0676},
journal = {J Periodontol},
pages = {640--649},
title = {Effects of intermittent fasting on periodontal inflammation and subgingival microbiota.},
url = {http://dx.doi.org/10.1002/JPER.23-0676},
volume = {95},
year = {2024}
}
TY - JOUR
AB - BACKGROUND: Studies on the impact of intermittent fasting on periodontal health are still scarce. Thus, this study evaluated the effects of long-term intermittent fasting on periodontal health and the subgingival microbiota. METHODS: This pilot study was part of a nonrandomized controlled trial. Overweight/obese participants (n = 14) entered an intermittent fasting program, specifically the 5:2 diet, in which they restricted caloric intake to about a quarter of the normal total daily caloric expenditure for two nonconsecutive days/week. Subjects underwent a thorough clinical and laboratory examination, including an assessment of their periodontal condition, at baseline and 6 months after starting the diet. Additionally, subgingival microbiota was assessed by 16S rRNA gene sequencing. RESULTS: After 6 months of intermittent fasting, weight, body mass index, C-reactive protein, hemoglobin A1c (HbA1c), and the cholesterol profile improved significantly (p < 0.05). Moreover, significant reductions were observed in bleeding on probing (p = 0.01) and the presence of shallow periodontal pockets after fasting (p < 0.001), while no significant change was seen in plaque index (p = 0.14). While we did not observe significant changes in α- or β-diversity of the subgingival microbiota related to dietary intervention (p > 0.05), significant differences were seen in the abundances of several taxa among individuals exhibiting ≥60% reduction (good responders) in probing pocket depth of 4-5 mm compared to those with <60% reduction (bad responders). CONCLUSION: Intermittent fasting decreased systemic and periodontal inflammation. Although the subgingival microbiota was unaltered by this intervention, apparent taxonomic variability was observed between good and bad responders.
AU - Lira-Junior,R
AU - Aogáin,MM
AU - Crncalo,E
AU - Ekberg,NR
AU - Chotirmall,SH
AU - Pettersson,S
AU - Gustafsson,A
AU - Brismar,K
AU - Bostanci,N
DO - 10.1002/JPER.23-0676
EP - 649
PY - 2024///
SP - 640
TI - Effects of intermittent fasting on periodontal inflammation and subgingival microbiota.
T2 - J Periodontol
UR - http://dx.doi.org/10.1002/JPER.23-0676
UR - https://www.ncbi.nlm.nih.gov/pubmed/38655661
VL - 95
ER -
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