BibTex format
@article{Kappel:2024:10.1038/s44259-024-00043-6,
author = {Kappel, D and Gifford, H and Brackin, A and Abdolrasouli, A and Eyre, DW and Jeffery, K and Schlenz, S and Aanensen, DM and Brown, CS and Borman, A and Johnson, E and Holmes, A and Armstrong-James, D and Fisher, MC and Rhodes, J},
doi = {10.1038/s44259-024-00043-6},
journal = {npj Antimicrobials and Resistance},
title = {Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant Candida auris},
url = {http://dx.doi.org/10.1038/s44259-024-00043-6},
volume = {2},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Candida auris is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant C. auris within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of C. auris introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates. We identify at least one introduction from Clade I and two from Clade III into the UK, and observe temporal and geographical evidence for multiple transmission events of antifungal drug resistant isolates between hospitals and identified local within-hospital patient-to-patient transmission events. Our study confirms outbreaks of drug-resistant C. auris are linked and that transmission amongst patients occurs, explaining local hospital outbreaks, and demonstrating a need for improved epidemiological surveillance of C. auris to protect patients and healthcare services.
AU - Kappel,D
AU - Gifford,H
AU - Brackin,A
AU - Abdolrasouli,A
AU - Eyre,DW
AU - Jeffery,K
AU - Schlenz,S
AU - Aanensen,DM
AU - Brown,CS
AU - Borman,A
AU - Johnson,E
AU - Holmes,A
AU - Armstrong-James,D
AU - Fisher,MC
AU - Rhodes,J
DO - 10.1038/s44259-024-00043-6
PY - 2024///
SN - 2731-8745
TI - Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant Candida auris
T2 - npj Antimicrobials and Resistance
UR - http://dx.doi.org/10.1038/s44259-024-00043-6
UR - http://hdl.handle.net/10044/1/114980
VL - 2
ER -