In this section
@article{Liu:2024:10.1016/j.celrep.2024.114906,
author = {Liu, K and Grover, M and Trusch, F and Vagena-Pantoula, C and Ippolito, D and Barkoulas, M},
doi = {10.1016/j.celrep.2024.114906},
journal = {Cell Reports},
title = {Paired C-type lectin receptors mediate specific recognition of divergent oomycete pathogens in C. elegans},
url = {http://dx.doi.org/10.1016/j.celrep.2024.114906},
volume = {43},
year = {2024}
}
TY - JOUR
AB - Innate immune responses can be triggered upon detection of pathogen- or damage-associated molecular patterns by host receptors that are often present on the surface of immune cells. While invertebrates like Caenorhabditis elegans lack professional immune cells, they still mount pathogen-specific responses. However, the identity of host receptors in the nematode remains poorly understood. Here, we show that C-type lectin receptors mediate species-specific recognition of divergent oomycetes in C. elegans. A CLEC-27/CLEC-35 pair is essential for recognition of the oomycete Myzocytiopsis humicola, while a CLEC-26/CLEC-36 pair is required for detection of Haptoglossa zoospora. Both clec pairs are transcriptionally regulated through a shared promoter by the conserved PRD-like homeodomain transcription factor CEH-37/OTX2 and act in sensory neurons and the anterior intestine to trigger a protective immune response in the epidermis. This system enables redundant tissue sensing of oomycete threats through canonical CLEC receptors and host defense via cross-tissue communication.
AU - Liu,K
AU - Grover,M
AU - Trusch,F
AU - Vagena-Pantoula,C
AU - Ippolito,D
AU - Barkoulas,M
DO - 10.1016/j.celrep.2024.114906
PY - 2024///
SN - 2211-1247
TI - Paired C-type lectin receptors mediate specific recognition of divergent oomycete pathogens in C. elegans
T2 - Cell Reports
UR - http://dx.doi.org/10.1016/j.celrep.2024.114906
UR - https://www.sciencedirect.com/science/article/pii/S2211124724012579
UR - http://hdl.handle.net/10044/1/115302
VL - 43
ER -
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