BibTex format
@article{Yuen:2024:10.1126/sciadv.ado9516,
author = {Yuen, ELH and Tumtas, Y and King, F and Ibrahim, T and Chan, LI and Evangelisti, E and Tulin, F and Skenar, J and Menke, FLH and Kamoun, S and Bubeck, D and Schornack, S and Bozkurt, TO},
doi = {10.1126/sciadv.ado9516},
journal = {Science Advances},
title = {A pathogen effector co-opts a host RabGAP protein to remodel pathogen interface and subvert defense-related secretion},
url = {http://dx.doi.org/10.1126/sciadv.ado9516},
volume = {10},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Pathogens have evolved sophisticated mechanisms to manipulate host cell membrane dynamics, a crucial adaptation to survive in hostile environments shaped by innate immune responses. Plant-derived membrane interfaces, engulfing invasive hyphal projections of fungal and oomycete pathogens, are prominent junctures dictating infection outcomes. Understanding how pathogens transform these host-pathogen interfaces to their advantage remains a key biological question. Here, we identified a conserved effector, secreted by plant pathogenic oomycetes, that co-opts a host Rab GTPase-activating protein (RabGAP), TOPGAP, to remodel the host-pathogen interface. The effector, PiE354, hijacks TOPGAP as a susceptibility factor to usurp its GAP activity on Rab8a, a key Rab GTPase crucial for defense-related secretion. By hijacking TOPGAP, PiE354 purges Rab8a from the plasma membrane, diverting Rab8a-mediated immune trafficking away from the pathogen interface. This mechanism signifies an uncanny evolutionary adaptation of a pathogen effector in co-opting a host regulatory component to subvert defense-related secretion, thereby providing unprecedented mechanistic insights into the reprogramming of host membrane dynamics by pathogens.
AU - Yuen,ELH
AU - Tumtas,Y
AU - King,F
AU - Ibrahim,T
AU - Chan,LI
AU - Evangelisti,E
AU - Tulin,F
AU - Skenar,J
AU - Menke,FLH
AU - Kamoun,S
AU - Bubeck,D
AU - Schornack,S
AU - Bozkurt,TO
DO - 10.1126/sciadv.ado9516
PY - 2024///
SN - 2375-2548
TI - A pathogen effector co-opts a host RabGAP protein to remodel pathogen interface and subvert defense-related secretion
T2 - Science Advances
UR - http://dx.doi.org/10.1126/sciadv.ado9516
UR - https://www.science.org/doi/10.1126/sciadv.ado9516
UR - http://hdl.handle.net/10044/1/115417
VL - 10
ER -