In this section
@article{Narayana:2024:10.1097/MCP.0000000000001131,
author = {Narayana, JK and Mac, Aogáin M and Hansbro, PM and Chotirmall, SH},
doi = {10.1097/MCP.0000000000001131},
journal = {Curr Opin Pulm Med},
title = {The bronchiectasis microbiome: current understanding and treatment implications.},
url = {http://dx.doi.org/10.1097/MCP.0000000000001131},
year = {2024}
}
TY - JOUR
AB - PURPOSE OF REVIEW: Advances in DNA sequencing and analysis of the respiratory microbiome highlight its close association with bronchiectasis phenotypes, revealing fresh opportunities for diagnosis, stratification, and personalized clinical intervention. An under-recognized condition, bronchiectasis is increasingly the subject of recent large-scale, multicentre, and longitudinal clinical studies including detailed analysis of the microbiome. In this review, we summarize recent progress in our understanding of the bronchiectasis microbiome within the context of its potential use in treatment decisions. RECENT FINDINGS: Diverse microbiome profiles exist in bronchiectasis, in line with the established disease heterogeneity including treatment response. Classical microbiology has established Pseudomonas aeruginosa and Haemophilus influenza as two microbial markers of disease, while holistic microbiome analysis has uncovered important associations with less common bacterial taxa including commensal an/or pathobiont species, including the emerging role of the fungal mycobiome, virome, and interactome. Integration of airway microbiomes with other high-dimensional biological and clinical datasets holds significant promise to determining treatable traits and mechanisms of disease related to the microbiome. SUMMARY: The bronchiectasis microbiome is an emerging and key area of study with significant implications for understanding bronchiectasis, influencing treatment decisions and ultimately improving patient outcomes.
AU - Narayana,JK
AU - Mac,Aogáin M
AU - Hansbro,PM
AU - Chotirmall,SH
DO - 10.1097/MCP.0000000000001131
PY - 2024///
TI - The bronchiectasis microbiome: current understanding and treatment implications.
T2 - Curr Opin Pulm Med
UR - http://dx.doi.org/10.1097/MCP.0000000000001131
UR - https://www.ncbi.nlm.nih.gov/pubmed/39492755
ER -
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