In this section
@article{Valdar:2006:10.1038/ng1840,
author = {Valdar, W and Solberg, LC and Gauguier, D and Burnett, S and Klenerman, P and Cookson, WO and Taylor, MS and Rawlins, JNP and Mott, R and Flint, J},
doi = {10.1038/ng1840},
journal = {Nat Genet},
pages = {879--887},
title = {Genome-wide genetic association of complex traits in heterogeneous stock mice.},
url = {http://dx.doi.org/10.1038/ng1840},
volume = {38},
year = {2006}
}
TY - JOUR
AB - Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress in the molecular dissection of complex traits in mice. Here we show that genome-wide high-resolution mapping of multiple phenotypes can be achieved using a stock of genetically heterogeneous mice. We developed a conservative and robust bootstrap analysis to map 843 QTLs with an average 95% confidence interval of 2.8 Mb. The QTLs contribute to variation in 97 traits, including models of human disease (asthma, type 2 diabetes mellitus, obesity and anxiety) as well as immunological, biochemical and hematological phenotypes. The genetic architecture of almost all phenotypes was complex, with many loci each contributing a small proportion to the total variance. Our data set, freely available at http://gscan.well.ox.ac.uk, provides an entry point to the functional characterization of genes involved in many complex traits.
AU - Valdar,W
AU - Solberg,LC
AU - Gauguier,D
AU - Burnett,S
AU - Klenerman,P
AU - Cookson,WO
AU - Taylor,MS
AU - Rawlins,JNP
AU - Mott,R
AU - Flint,J
DO - 10.1038/ng1840
EP - 887
PY - 2006///
SN - 1061-4036
SP - 879
TI - Genome-wide genetic association of complex traits in heterogeneous stock mice.
T2 - Nat Genet
UR - http://dx.doi.org/10.1038/ng1840
UR - https://www.ncbi.nlm.nih.gov/pubmed/16832355
VL - 38
ER -
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