@article{Fuks:2014:10.1289/ehp.1307725,
author = {Fuks, KB and Weinmayr, G and Foraster, M and Dratva, J and Hampel, R and Houthuijs, D and Oftedal, B and Oudin, A and Panasevich, S and Penell, J and Sommar, JN and Sorensen, M and Tiittanen, P and Wolf, K and Xun, WW and Aguilera, I and Basagana, X and Beelen, R and Bots, ML and Brunekreef, B and Bueno-de-Mesquita, HB and Caracciolo, B and Cirach, M and de, Faire U and de, Nazelle A and Eeftens, M and Elosua, R and Erbel, R and Forsberg, B and Fratiglioni, L and Gaspoz, J-M and Hilding, A and Jula, A and Korek, M and Kraemer, U and Kuenzli, N and Lanki, T and Leander, K and Magnusson, PKE and Marrugat, J and Nieuwenhuijsen, MJ and Oestenson, C-G and Pedersen, NL and Pershagen, G and Phuleria, HC and Probst-Hensch, NM and Raaschou-Nielsen, O and Schaffner, E and Schikowski, T and Schindler, C and Schwarze, PE and Sogaard, AJ and Sugiri, D and Swart, WJR and Tsai, M-Y and Turunen, AW and Vineis, P and Peters, A and Hoffmann, B},
doi = {10.1289/ehp.1307725},
journal = {Environmental Health Perspectives},
pages = {896--905},
title = {Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European study of cohorts for air pollution effects (ESCAPE)},
url = {http://dx.doi.org/10.1289/ehp.1307725},
volume = {122},
year = {2014}
}

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TY  - JOUR
AB  - Background: Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific.Objectives: We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hypertension in European populations.Methods: We analyzed 15 population-based cohorts, participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE). We modeled residential exposure to particulate matter and nitrogen oxides with land use regression using a uniform protocol. We assessed traffic exposure with traffic indicator variables. We analyzed systolic and diastolic BP in participants medicated and nonmedicated with BP-lowering medication (BPLM) separately, adjusting for personal and area-level risk factors and environmental noise. Prevalent hypertension was defined as ≥ 140 mmHg systolic BP, or ≥ 90 mmHg diastolic BP, or intake of BPLM. We combined cohort-specific results using random-effects meta-analysis.Results: In the main meta-analysis of 113,926 participants, traffic load on major roads within 100 m of the residence was associated with increased systolic and diastolic BP in nonmedicated participants [0.35 mmHg (95% CI: 0.02, 0.68) and 0.22 mmHg (95% CI: 0.04, 0.40) per 4,000,000 vehicles × m/day, respectively]. The estimated odds ratio (OR) for prevalent hypertension was 1.05 (95% CI: 0.99, 1.11) per 4,000,000 vehicles × m/day. Modeled air pollutants and BP were not clearly associated.Conclusions: In this first comprehensive meta-analysis of European population-based cohorts, we observed a weak positive association of high residential traffic exposure with BP in nonmedicated participants, and an elevated OR for prevalent hypertension. The relationship of modeled air pollutants with BP was inconsistent.
AU  - Fuks,KB
AU  - Weinmayr,G
AU  - Foraster,M
AU  - Dratva,J
AU  - Hampel,R
AU  - Houthuijs,D
AU  - Oftedal,B
AU  - Oudin,A
AU  - Panasevich,S
AU  - Penell,J
AU  - Sommar,JN
AU  - Sorensen,M
AU  - Tiittanen,P
AU  - Wolf,K
AU  - Xun,WW
AU  - Aguilera,I
AU  - Basagana,X
AU  - Beelen,R
AU  - Bots,ML
AU  - Brunekreef,B
AU  - Bueno-de-Mesquita,HB
AU  - Caracciolo,B
AU  - Cirach,M
AU  - de,Faire U
AU  - de,Nazelle A
AU  - Eeftens,M
AU  - Elosua,R
AU  - Erbel,R
AU  - Forsberg,B
AU  - Fratiglioni,L
AU  - Gaspoz,J-M
AU  - Hilding,A
AU  - Jula,A
AU  - Korek,M
AU  - Kraemer,U
AU  - Kuenzli,N
AU  - Lanki,T
AU  - Leander,K
AU  - Magnusson,PKE
AU  - Marrugat,J
AU  - Nieuwenhuijsen,MJ
AU  - Oestenson,C-G
AU  - Pedersen,NL
AU  - Pershagen,G
AU  - Phuleria,HC
AU  - Probst-Hensch,NM
AU  - Raaschou-Nielsen,O
AU  - Schaffner,E
AU  - Schikowski,T
AU  - Schindler,C
AU  - Schwarze,PE
AU  - Sogaard,AJ
AU  - Sugiri,D
AU  - Swart,WJR
AU  - Tsai,M-Y
AU  - Turunen,AW
AU  - Vineis,P
AU  - Peters,A
AU  - Hoffmann,B
DO  - 10.1289/ehp.1307725
EP  - 905
PY  - 2014///
SN  - 0091-6765
SP  - 896
TI  - Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European study of cohorts for air pollution effects (ESCAPE)
T2  - Environmental Health Perspectives
UR  - http://dx.doi.org/10.1289/ehp.1307725
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341714600015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/54438
VL  - 122
ER  - 

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