@article{Khan:2014:10.1371/journal.pone.0108715,
author = {Khan, AE and Scheelbeek, PFD and Shilpi, AB and Chan, Q and Mojumder, SK and Rahman, A and Haines, A and Vineis, P},
doi = {10.1371/journal.pone.0108715},
journal = {PLoS One},
pages = {1--9},
title = {Salinity in drinking water and the risk of (pre)eclampsia and gestational hypertension in coastal Bangladesh: A case-control study},
url = {http://dx.doi.org/10.1371/journal.pone.0108715},
volume = {9},
year = {2014}
}

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TY  - JOUR
AB  - BackgroundHypertensive disorders in pregnancy are among the leading causes of maternal and perinatal death in low-income countries, but the aetiology remains unclear. We investigated the relationship between salinity in drinking water and the risk of (pre)eclampsia and gestational hypertension in a coastal community.MethodsA population-based case-control study was conducted in Dacope, Bangladesh among 202 pregnant women with (pre)eclampsia or gestational hypertension, enrolled from the community served by the Upazilla Health Complex, Dacope and 1,006 matched controls from the same area. Epidemiological and clinical data were obtained from all participants. Urinary sodium and sodium levels in drinking water were measured. Logistic regression was used to calculate odds ratios, and 95% confidence intervals.FindingsDrinking water sources had exceptionally high sodium levels (mean 516.6 mg/L, S.D 524.2). Women consuming tube-well (groundwater) were at a higher disease risk than rainwater users (p<0.001). Adjusted risks for (pre)eclampsia and gestational hypertension considered together increased in a dose-response manner for increasing sodium concentrations (300.01–600 mg/L, 600.1–900 mg/L, >900.01 mg/L, compared to <300 mg/L) in drinking water (ORs 3.30 [95% CI 2.00–5.51], 4.40 [2.70–7.25] and 5.48 [3.30–9.11] (p-trend<0.001). Significant associations were seen for both (pre)eclampsia and gestational hypertension separately.InterpretationSalinity in drinking water is associated with increased risk of (pre)eclampsia and gestational hypertension in this population. Given that coastal populations in countries such as Bangladesh are confronted with high salinity exposure, which is predicted to further increase as a result of sea level rise and other environmental influences, it is imperative to develop and evaluate affordable approaches to providing water with low salt content.
AU  - Khan,AE
AU  - Scheelbeek,PFD
AU  - Shilpi,AB
AU  - Chan,Q
AU  - Mojumder,SK
AU  - Rahman,A
AU  - Haines,A
AU  - Vineis,P
DO  - 10.1371/journal.pone.0108715
EP  - 9
PY  - 2014///
SN  - 1932-6203
SP  - 1
TI  - Salinity in drinking water and the risk of (pre)eclampsia and gestational hypertension in coastal Bangladesh: A case-control study
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0108715
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108715
UR  - http://hdl.handle.net/10044/1/81991
VL  - 9
ER  - 

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