In this section
@article{Ji:2022:10.1007/s10439-022-02999-w,
author = {Ji, S and Ghajari, M and Mao, H and Kraft, RH and Hajiaghamemar, M and Panzer, MB and Willinger, R and Gilchrist, MD and Kleiven, S and Stitzel, JD},
doi = {10.1007/s10439-022-02999-w},
journal = {Annals of Biomedical Engineering},
pages = {1389--1408},
title = {Use of brain biochemical models for monitoring impact exposure in contact sports},
url = {http://dx.doi.org/10.1007/s10439-022-02999-w},
volume = {50},
year = {2022}
}
TY - JOUR
AB - Head acceleration measurement sensors are now widely deployed in the field to monitor head kinematic exposure in contact sports. The wealth of impact kinematics data provides valuable, yet challenging, opportunities to study the biomechanical basis of mild traumatic brain injury (mTBI) and subconcussive kinematic exposure. Head impact kinematics are translated into brain mechanical responses through physics-based computational simulations using validated brain models to study the mechanisms of injury. First, this article reviews representative legacy and contemporary brain biomechanical models primarily used for blunt impact simulation. Then, it summarizes perspectives regarding the development and validation of these models, and discusses how simulation results can be interpreted to facilitate injury risk assessment and head acceleration exposure monitoring in the context of contact sports. Recommendations and consensus statements are presented on the use of validated brain models in conjunction with kinematic sensor data to understand the biomechanics of mTBI and subconcussion. Mainly, there is general consensus that validated brain models have strong potential to improve injury prediction and interpretation of subconcussive kinematic exposure over global head kinematics alone. Nevertheless, a major roadblock to this capability is the lack of sufficient data encompassing different sports, sex, age and other factors. The authors recommend further integration of sensor data and simulations with modern data science techniques to generate large datasets of exposures and predicted brain responses along with associated clinical findings. These efforts are anticipated to help better understand the biomechanical basis of mTBI and improve the effectiveness in monitoring kinematic exposure in contact sports for risk and injury mitigation purposes.
AU - Ji,S
AU - Ghajari,M
AU - Mao,H
AU - Kraft,RH
AU - Hajiaghamemar,M
AU - Panzer,MB
AU - Willinger,R
AU - Gilchrist,MD
AU - Kleiven,S
AU - Stitzel,JD
DO - 10.1007/s10439-022-02999-w
EP - 1408
PY - 2022///
SN - 0090-6964
SP - 1389
TI - Use of brain biochemical models for monitoring impact exposure in contact sports
T2 - Annals of Biomedical Engineering
UR - http://dx.doi.org/10.1007/s10439-022-02999-w
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000828941300003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://link.springer.com/content/pdf/10.1007/s10439-022-02999-w.pdf
UR - http://hdl.handle.net/10044/1/98906
VL - 50
ER -
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