BibTex format
@article{Zivanovic:2023:10.1002/ctm2.1507,
author = {Zivanovic, N and Öner, D and Abraham, Y and McGinley, J and Drysdale, SB and Wildenbeest, JG and Crabbe, M and Vanhoof, G and Thys, K and Thwaites, RS and Robinson, H and Bont, L and Openshaw, PJM and Martinón-Torres, F and RESCEU, Investigators and Pollard, AJ and Aerssens, J},
doi = {10.1002/ctm2.1507},
journal = {Clinical and Translational Medicine},
title = {Single-cell immune profiling reveals markers of emergency myelopoiesis that distinguish severe from mild respiratory syncytial virus disease in infants},
url = {http://dx.doi.org/10.1002/ctm2.1507},
volume = {13},
year = {2023}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Whereas most infants infected with respiratory syncytial virus (RSV) show no or only mild symptoms, an estimated 3 million children under five are hospitalized annually due to RSV disease. This study aimed to investigate biological mechanisms and associated biomarkers underlying RSV disease heterogeneity in young infants, enabling the potential to objectively categorize RSV-infected infants according to their medical needs. Immunophenotypic and functional profiling demonstrated the emergence of immature and progenitor-like neutrophils, proliferative monocytes (HLA-DRLow , Ki67+), impaired antigen-presenting function, downregulation of T cell response and low abundance of HLA-DRLow B cells in severe RSV disease. HLA-DRLow monocytes were found as a hallmark of RSV-infected infants requiring hospitalization. Complementary transcriptomics identified genes associated with disease severity and pointed to the emergency myelopoiesis response. These results shed new light on mechanisms underlying the pathogenesis and development of severe RSV disease and identified potential new candidate biomarkers for patient stratification.
AU - Zivanovic,N
AU - Öner,D
AU - Abraham,Y
AU - McGinley,J
AU - Drysdale,SB
AU - Wildenbeest,JG
AU - Crabbe,M
AU - Vanhoof,G
AU - Thys,K
AU - Thwaites,RS
AU - Robinson,H
AU - Bont,L
AU - Openshaw,PJM
AU - Martinón-Torres,F
AU - RESCEU,Investigators
AU - Pollard,AJ
AU - Aerssens,J
DO - 10.1002/ctm2.1507
PY - 2023///
SN - 2001-1326
TI - Single-cell immune profiling reveals markers of emergency myelopoiesis that distinguish severe from mild respiratory syncytial virus disease in infants
T2 - Clinical and Translational Medicine
UR - http://dx.doi.org/10.1002/ctm2.1507
UR - https://www.ncbi.nlm.nih.gov/pubmed/38115705
UR - https://onlinelibrary.wiley.com/doi/10.1002/ctm2.1507
VL - 13
ER -