@article{Dabas:2024:10.1016/j.eurpolymj.2024.113183,
author = {Dabas, R and Kamaly, N},
doi = {10.1016/j.eurpolymj.2024.113183},
journal = {European Polymer Journal},
title = {Redox-Responsive Nanogels for Precision Protein Delivery},
url = {http://dx.doi.org/10.1016/j.eurpolymj.2024.113183},
volume = {215},
year = {2024}
}

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TY  - JOUR
AB  - Redox-responsive drug carriers present a therapeutically viable delivery platform owing to their ability to leverage the intracellular redox environment. In this work, we describe a facile, one-pot aqueous-based synthetic methodology for encapsulating sensitive biological payloads within redox-responsive crosslinked nanogels. We systematically evaluate the impact of various disulphide-based crosslinkers on the morphology, stability, encapsulation and loading capacities of these nanogels. In vitro assessments were conducted to elucidate the ease of delivery of functional protein payloads, using fluorescently-labelled bovine serum albumin and the enzyme, paraoxonase-1. The nanogels demonstrate promising delivery efficiencies with minimal cytotoxicity in vitro. The simplicity of their synthesis, along with the precise control achieved in nanogel degradation and payload release kinetics, not only enriches our understanding of redox-responsive nanosystems but also underscores their potential to catalyze transformative advancements in intracellular protein delivery.
AU  - Dabas,R
AU  - Kamaly,N
DO  - 10.1016/j.eurpolymj.2024.113183
PY  - 2024///
SN  - 0014-3057
TI  - Redox-Responsive Nanogels for Precision Protein Delivery
T2  - European Polymer Journal
UR  - http://dx.doi.org/10.1016/j.eurpolymj.2024.113183
VL  - 215
ER  - 

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