Citation

BibTex format

@article{Lubin:2024:10.1084/jem.20220867,
author = {Lubin, R and Patel, AA and Mackerodt, J and Zhang, Y and Gvili, R and Mulder, K and Dutertre, C-A and Jalali, P and Glanville, JRW and Hazan, I and Sridharan, N and Rivkin, G and Akarca, A and Marafioti, T and Gilroy, DW and Kandel, L and Mildner, A and Wilensky, A and Asquith, B and Ginhoux, F and Macallan, D and Yona, S},
doi = {10.1084/jem.20220867},
journal = {Journal of Experimental Medicine},
title = {The lifespan and kinetics of human dendritic cell subsets and their precursors in health and inflammation},
url = {http://dx.doi.org/10.1084/jem.20220867},
volume = {221},
year = {2024}
}
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TY  - JOUR
AB  - Dendritic cells (DC) are specialized mononuclear phagocytes that link innate and adaptive immunity. They comprise two principal subsets: plasmacytoid DC (pDC) and conventional DC (cDC). Understanding the generation, differentiation, and migration of cDC is critical for immune homeostasis. Through human in vivo deuterium-glucose labeling, we observed the rapid appearance of AXL+ Siglec6+ DC (ASDC) in the bloodstream. ASDC circulate for ∼2.16 days, while cDC1 and DC2 circulate for ∼1.32 and ∼2.20 days, respectively, upon release from the bone marrow. Interestingly, DC3, a cDC subset that shares several similarities with monocytes, exhibits a labeling profile closely resembling that of DC2. In a human in vivo model of cutaneous inflammation, ASDC were recruited to the inflammatory site, displaying a distinctive effector signature. Taken together, these results quantify the ephemeral circulating lifespan of human cDC and propose functions of cDC and their precursors that are rapidly recruited to sites of inflammation.
AU  - Lubin,R
AU  - Patel,AA
AU  - Mackerodt,J
AU  - Zhang,Y
AU  - Gvili,R
AU  - Mulder,K
AU  - Dutertre,C-A
AU  - Jalali,P
AU  - Glanville,JRW
AU  - Hazan,I
AU  - Sridharan,N
AU  - Rivkin,G
AU  - Akarca,A
AU  - Marafioti,T
AU  - Gilroy,DW
AU  - Kandel,L
AU  - Mildner,A
AU  - Wilensky,A
AU  - Asquith,B
AU  - Ginhoux,F
AU  - Macallan,D
AU  - Yona,S
DO  - 10.1084/jem.20220867
PY  - 2024///
SN  - 0022-1007
TI  - The lifespan and kinetics of human dendritic cell subsets and their precursors in health and inflammation
T2  - Journal of Experimental Medicine
UR  - http://dx.doi.org/10.1084/jem.20220867
UR  - http://hdl.handle.net/10044/1/115509
VL  - 221
ER  -
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