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BibTex format

@article{Rockall:2014:10.1158/1078-0432.CCR-13-2634,
author = {Rockall, AG and Avril, N and Lam, R and Iannone, R and Mozley, PD and Parkinson, C and Bergstrom, D and Sala, E and Sarker, S-J and McNeish, IA and Brenton, JD},
doi = {10.1158/1078-0432.CCR-13-2634},
journal = {Clinical Cancer Research},
pages = {2751--2760},
title = {Repeatability of quantitative FDG-PET/CT and contrast-enhanced CT in recurrent ovarian carcinoma: Test-retest measurements for tumor FDG uptake, diameter, and volume},
url = {http://dx.doi.org/10.1158/1078-0432.CCR-13-2634},
volume = {20},
year = {2014}
}
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TY  - JOUR
AB  - Purpose: Repeatability of baseline FDG-PET/CT measurements has not been tested in ovarian cancer. This dual-center, prospective study assessed variation in tumor 2[18F]fluoro-2-deoxy-D-glucose (FDG) uptake, tumor diameter, and tumor volume from sequential FDG-PET/CT and contrast-enhanced computed tomography (CECT) in patients with recurrent platinum-sensitive ovarian cancer.Experimental Design: Patients underwent two pretreatment baseline FDG-PET/CT (n = 21) and CECT (n = 20) at two clinical sites with different PET/CT instruments. Patients were included if they had at least one target lesion in the abdomen with a standardized uptake value (SUV) maximum (SUVmax) of ≥2.5 and a long axis diameter of ≥15 mm. Two independent reading methods were used to evaluate repeatability of tumor diameter and SUV uptake: on site and at an imaging clinical research organization (CRO). Tumor volume reads were only performed by CRO. In each reading set, target lesions were independently measured on sequential imaging.Results: Median time between FDG-PET/CT was two days (range 1–7). For site reads, concordance correlation coefficients (CCC) for SUVmean, SUVmax, and tumor diameter were 0.95, 0.94, and 0.99, respectively. Repeatability coefficients were 16.3%, 17.3%, and 8.8% for SUVmean, SUVmax, and tumor diameter, respectively. Similar results were observed for CRO reads. Tumor volume CCC was 0.99 with a repeatability coefficient of 28.1%.Conclusions: There was excellent test–retest repeatability for FDG-PET/CT quantitative measurements across two sites and two independent reading methods. Cutoff values for determining change in SUVmean, SUVmax, and tumor volume establish limits to determine metabolic and/or volumetric response to treatment in platinum-sensitive relapsed ovarian cancer.
AU  - Rockall,AG
AU  - Avril,N
AU  - Lam,R
AU  - Iannone,R
AU  - Mozley,PD
AU  - Parkinson,C
AU  - Bergstrom,D
AU  - Sala,E
AU  - Sarker,S-J
AU  - McNeish,IA
AU  - Brenton,JD
DO  - 10.1158/1078-0432.CCR-13-2634
EP  - 2760
PY  - 2014///
SN  - 1078-0432
SP  - 2751
TI  - Repeatability of quantitative FDG-PET/CT and contrast-enhanced CT in recurrent ovarian carcinoma: Test-retest measurements for tumor FDG uptake, diameter, and volume
T2  - Clinical Cancer Research
UR  - http://dx.doi.org/10.1158/1078-0432.CCR-13-2634
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336720200026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://clincancerres.aacrjournals.org/content/20/10/2751
VL  - 20
ER  -
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