Accelerating our understanding of infectious diseases
Infecting people on purpose?
Learn how our Imperial experts are pioneering this approach to tackle infectious diseases like COVID-19 and malaria in our feature on our human challenge studies.
A human challenge study is a carefully managed medical research study, during which volunteers are intentionally given an infection in a safe way with healthcare support.
Human challenge studies have a unique ability to investigate and understand the onset and development of disease in a controlled environment. They allow researchers to tease out complicated interactions and point out potential targets for prevention, vaccines or treatment that cannot be seen in patients who are infected naturally.
Imperial College London has successfully led several such studies to better understand a range of infectious diseases and, in February 2021, ran the world’s first human challenge study for COVID-19.
Imperial also hosts HIC-Vac, a Wellcome-funded international network of researchers developing human infection challenge studies to accelerate the development of vaccines against pathogens of high global impact.
All human challenge studies carried out by Imperial require ethical approval from the UK Health Research Authority. Trials are designed to minimise risk to study participants, and the health and safety of participants are paramount.
Mucosal Immunity in human Coronavirus Challenge (MusiCC) project
Led by Imperial College London and Professor Chris Chiu, this consortium is an international group of researchers specialising in human challenge studies to develop advanced virus-blocking vaccines.
Announced in 2024, it is laying the crucial groundwork needed to develop the next generation of COVID-19 vaccines that could stop SARS-CoV-2 and other coronaviruses from infecting people in the first place.
The project is co-funded by US $57m (£44m) from the European Union’s Horizon Europe Programme and CEPI (the Coalition for Epidemic Preparedness Innovations).
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