In this section
@article{Danson:2019:10.1016/j.jmb.2019.04.022,
author = {Danson, A and Jovanovic, M and Buck, M and Zhang, X},
doi = {10.1016/j.jmb.2019.04.022},
journal = {Journal of Molecular Biology},
title = {Mechanisms of s54-dependent transcription initiation and regulation},
url = {http://dx.doi.org/10.1016/j.jmb.2019.04.022},
year = {2019}
}
TY - JOUR
AB - Cellular RNA polymerase is a multi-subunit macromolecular assembly responsible for gene transcription, a highly regulated process conserved from bacteria to humans. In bacteria, sigma factors are employed to mediate gene-specific expression in response to a variety of environmental conditions. The major variant σ factor, σ54, has a specific role in stress responses. Unlike σ70-dependent transcription, which often can spontaneously proceed to initiation, σ54-dependent transcription requires an additional ATPase protein for activation. As a result, structures of a number of distinct functional states during the dynamic process of transcription initiation have been captured using the σ54 system with both x-ray crystallography and cryo electron microscopy, furthering our understanding of σ54-dependent transcription initiation and DNA opening. Comparisons with σ70 and eukaryotic polymerases reveal unique and common features during transcription initiation.
AU - Danson,A
AU - Jovanovic,M
AU - Buck,M
AU - Zhang,X
DO - 10.1016/j.jmb.2019.04.022
PY - 2019///
SN - 0022-2836
TI - Mechanisms of s54-dependent transcription initiation and regulation
T2 - Journal of Molecular Biology
UR - http://dx.doi.org/10.1016/j.jmb.2019.04.022
UR - http://hdl.handle.net/10044/1/70236
ER -
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