In this section
@article{Costa:2023:10.1038/s41579-023-00974-3,
author = {Costa, TRD and Patkowski, JB and Mace, K and Christie, PJ and Waksman, G},
doi = {10.1038/s41579-023-00974-3},
journal = {Nature Reviews Microbiology},
pages = {170--185},
title = {Structural and functional diversity of type IV secretion systems},
url = {http://dx.doi.org/10.1038/s41579-023-00974-3},
volume = {22},
year = {2023}
}
TY - JOUR
AB - Considerable progress has been made in recent years in the structural and molecular biology of type IV secretion systems in Gram-negative bacteria. The latest advances have substantially improved our understanding of the mechanisms underlying the recruitment and delivery of DNA and protein substrates to the extracellular environment or target cells. In this Review, we aim to summarize these exciting structural and molecular biology findings and to discuss their functional implications for substrate recognition, recruitment and translocation, as well as the biogenesis of extracellular pili. We also describe adaptations necessary for deploying a breadth of processes, such as bacterial survival, host–pathogen interactions and biotic and abiotic adhesion. We highlight the functional and structural diversity that allows this extremely versatile secretion superfamily to function under different environmental conditions and in different bacterial species. Additionally, we emphasize the importance of further understanding the mechanism of type IV secretion, which will support us in combating antimicrobial resistance and treating type IV secretion system-related infections.
AU - Costa,TRD
AU - Patkowski,JB
AU - Mace,K
AU - Christie,PJ
AU - Waksman,G
DO - 10.1038/s41579-023-00974-3
EP - 185
PY - 2023///
SN - 1740-1526
SP - 170
TI - Structural and functional diversity of type IV secretion systems
T2 - Nature Reviews Microbiology
UR - http://dx.doi.org/10.1038/s41579-023-00974-3
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:001080723600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR - https://www.nature.com/articles/s41579-023-00974-3
VL - 22
ER -
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