In this section
@article{Grover:2024:10.1371/journal.pbio.3002543,
author = {Grover, M and Gang, SS and Troemel, ER and Barkoulas, M},
doi = {10.1371/journal.pbio.3002543},
journal = {PLoS Biology},
pages = {1--21},
title = {Proteasome inhibition triggers tissue-specific immune responses against different pathogens in C. elegans},
url = {http://dx.doi.org/10.1371/journal.pbio.3002543},
volume = {22},
year = {2024}
}
TY - JOUR
AB - Protein quality control pathways play important roles in resistance against pathogen infection. For example, the conserved transcription factor SKN-1/NRF up-regulates proteostasis capacity after blockade of the proteasome and also promotes resistance against bacterial infection in the nematode Caenorhabditis elegans. SKN-1/NRF has 3 isoforms, and the SKN-1A/NRF1 isoform, in particular, regulates proteasomal gene expression upon proteasome dysfunction as part of a conserved bounce-back response. We report here that, in contrast to the previously reported role of SKN-1 in promoting resistance against bacterial infection, loss-of-function mutants in skn-1a and its activating enzymes ddi-1 and png-1 show constitutive expression of immune response programs against natural eukaryotic pathogens of C. elegans. These programs are the oomycete recognition response (ORR), which promotes resistance against oomycetes that infect through the epidermis, and the intracellular pathogen response (IPR), which promotes resistance against intestine-infecting microsporidia. Consequently, skn-1a mutants show increased resistance to both oomycete and microsporidia infections. We also report that almost all ORR/IPR genes induced in common between these programs are regulated by the proteasome and interestingly, specific ORR/IPR genes can be induced in distinct tissues depending on the exact trigger. Furthermore, we show that increasing proteasome function significantly reduces oomycete-mediated induction of multiple ORR markers. Altogether, our findings demonstrate that proteasome regulation keeps innate immune responses in check in a tissue-specific manner against natural eukaryotic pathogens of the C. elegans epidermis and intestine.
AU - Grover,M
AU - Gang,SS
AU - Troemel,ER
AU - Barkoulas,M
DO - 10.1371/journal.pbio.3002543
EP - 21
PY - 2024///
SN - 1544-9173
SP - 1
TI - Proteasome inhibition triggers tissue-specific immune responses against different pathogens in C. elegans
T2 - PLoS Biology
UR - http://dx.doi.org/10.1371/journal.pbio.3002543
UR - https://www.ncbi.nlm.nih.gov/pubmed/38466732
UR - https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002543
UR - http://hdl.handle.net/10044/1/110233
VL - 22
ER -
Interested in studying a PhD at the Department of Life Sciences? Find out more about postgraduate research opportunties.